TAK 715

Pricing Availability Delivery Time Qty
Cat.No. 4254 - TAK 715 | C24H21N3OS | CAS No. 303162-79-0
Description: Potent p38 MAPK inhibitor; anti-inflammatory
Chemical Name: N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα). Also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 kinases by more than 80%, including CK1δ/ε. Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable.

Compound Libraries

TAK 715 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 399.51
Formula C24H21N3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 303162-79-0
PubChem ID 90488922
InChI Key BRYAJHADJWBFQY-UHFFFAOYSA-N
Smiles CCC1=NC(C3=CC(C)=CC=C3)=C(C2=C(NC(C4=CC=CC=C4)=O)N=CC=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.95 100
ethanol 19.98 50

Preparing Stock Solutions

The following data is based on the product molecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Miwatashi et al (2005) Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-{2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J.Med.Chem. 48 5966 PMID: 16162000

Verkaar et al (2011) Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Chem.Biol. 18 485 PMID: 21513885


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View Related Products by Product Action

View all p38 MAPK Inhibitors

Keywords: TAK715 p38 MAPK inhibitors Mitogen-activated protein kinase anti-inflammatory inhibits wnt b-catenin inhibitor beta-catenin casein kinase p38

Citations for TAK 715

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Literature in this Area

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Cancer Research Product Guide

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  • Cancer Metabolism
  • Epigenetics in Cancer
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  • Cell Cycle and DNA Damage Repair
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A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for TAK 715

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

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