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Description: Inhibitor of Wnt/β-catenin signaling
Chemical Name: N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for WIC1

WIC1 is an inhibitor of the canonical Wnt/β-catenin signaling pathway. In vitro, it reduces ABSC (Airway Basal Stem Cell) proliferation and induces ciliated epithelial cell differentiation, in a model of squamous lung cancer. WIC1 also represses the phosphorylation of β-cateninY489 and Tp63 expression.

Technical Data for WIC1

M. Wt 377.44
Formula C22H23N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 943083-58-7
PubChem ID 24746859
Smiles CCN1CCN(C2=CC=C(C=C2)NC(C3=CC4=CC=CC=C4OC3=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WIC1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 0.75 2 with gentle warming

Preparing Stock Solutions for WIC1

The following data is based on the product molecular weight 377.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.02 mM 132.47 mL 662.36 mL 1324.71 mL
0.1 mM 26.49 mL 132.47 mL 264.94 mL
0.2 mM 13.25 mL 66.24 mL 132.47 mL
1 mM 2.65 mL 13.25 mL 26.49 mL

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References for WIC1

References are publications that support the biological activity of the product.

Aros et al (2020) High-throughput drug screening identifies a potent Wnt inhibitor that promotes airway basal stem cell homeostasis. Cell Rep. 30 2055 PMID: 32075752

If you know of a relevant reference for WIC1, please let us know.

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Keywords: WIC1, WIC1 supplier, canonical, Wnt, pathway, signaling, signalling, inhibitors, inhibits, catenin, Airway, Basal, Stem, Cell, ABSC, proliferation, β-cateninY489, Beta-catenin, 7580, Tocris Bioscience

Citations for WIC1

Citations are publications that use Tocris products.

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Pathways for WIC1

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.