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Biological Activity for WIC1
WIC1 is an inhibitor of the canonical Wnt/β-catenin signaling pathway. In vitro, it reduces ABSC (Airway Basal Stem Cell) proliferation and induces ciliated epithelial cell differentiation, in a model of squamous lung cancer. WIC1 also represses the phosphorylation of β-cateninY489 and Tp63 expression.
Technical Data for WIC1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WIC1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||0.75||2 with gentle warming|
Preparing Stock Solutions for WIC1
The following data is based on the product molecular weight 377.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.02 mM||132.47 mL||662.36 mL||1324.71 mL|
|0.1 mM||26.49 mL||132.47 mL||264.94 mL|
|0.2 mM||13.25 mL||66.24 mL||132.47 mL|
|1 mM||2.65 mL||13.25 mL||26.49 mL|
References for WIC1
References are publications that support the biological activity of the product.
Aros et al (2020) High-throughput drug screening identifies a potent Wnt inhibitor that promotes airway basal stem cell homeostasis. Cell Rep. 30 2055 PMID: 32075752
If you know of a relevant reference for WIC1, please let us know.
Keywords: WIC1, WIC1 supplier, canonical, Wnt, pathway, signaling, signalling, inhibitors, inhibits, catenin, Airway, Basal, Stem, Cell, ABSC, proliferation, β-cateninY489, Beta-catenin, 7580, Tocris Bioscience
Citations for WIC1
Citations are publications that use Tocris products.
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Literature in this Area
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