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Description: Selective peptide-based β-catenin Degrader (PROTAC®)
Purity: ≥95% (HPLC)
Literature (4)

Biological Activity for xStAx-VHLL

xStAx-VHLL is a selective peptide-based β-catenin Degrader (PROTAC®). Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.

β-catenin antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF1329 and NBP1-54467.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for xStAx-VHLL

M. Wt 3231.89
Formula C154H244N48O29

(Modifications: Arg-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-6 and X-10 stapled together with a double bond, Arg-17 = Arg-Ahx, Pro-24 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@](C)(C(N[C@H](C(N[C@H](C(N[C@H]2CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC/C=C\CCC[C@@](C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@@H](CCC3)C(N[C@H](C(N[C@H](C(N4[C@@H](CCC4)C(N)=O)=O)[C@H](CC)C)=O)CC5=CC=C(O)C=C5)=O)=O)C)=O)CC(C)C)=O)C)=O)=O)CCCNC(N)=N)=O)CC6=CNC7=C6C=CC=C7)=O)C(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(C)C)=O)CC8=CN=CN8)=O)NC2=O)=O)CCCNC(N)=N)=O)=O)CC9=CNC%10=C9C=CC=C%10)=O)CCCNC(N)=N)[C@@H](NC(C)=O)CCCNC(N)=N.O=C(N[C@H](C(N[C@H](C(N%11CCC[C@H]%11C(N[C@H](C(N[C@](C)(C(N[C@H](C(N[C@H](C(N[C@H]%12CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC/C=C/CCC[C@@](C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N%13[C@@H](CCC%13)C(N[C@H](C(N[C@H](C(N%14[C@@H](CCC%14)C(N)=O)=O)[C@H](CC)C)=O)CC%15=CC=C(O)C=C%15)=O)=O)C)=O)CC(C)C)=O)C)=O)=O)CCCNC(N)=N)=O)CC%16=CNC%17=C%16C=CC=C%17)=O)C(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(C)C)=O)CC%18=CN=CN%18)=O)NC%12=O)=O)CCCNC(N)=N)=O)=O)CC%19=CNC%20=C%19C=CC=C%20)=O)CCCNC(N)=N)[C@@H](NC(C)=O)CCCNC(N)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for xStAx-VHLL

Solubility Soluble to 1 mg/ml in water

Product Datasheets for xStAx-VHLL

Certificate of Analysis / Product Datasheet
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References for xStAx-VHLL

References are publications that support the biological activity of the product.

Liao et al (2020) A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discov. 6 35 PMID: 32550000

If you know of a relevant reference for xStAx-VHLL, please let us know.

Keywords: xStAx-VHLL, xStAx-VHLL supplier, β, beta, B, catenin, wnt, signaling, active, degraders, degrades, targeted, protein, degradation, TPD, PROTAC, PROTACs, selective, Protein, Degraders, Beta-catenin, 7298, Tocris Bioscience

Citations for xStAx-VHLL

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Literature in this Area

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