iCRT 14

Pricing Availability Delivery Time Qty
Cat.No. 4299 - iCRT 14 | C21H17N3O2S | CAS No. 677331-12-3
Description: Inhibits β-catenin-responsive transcription (CRT)
Chemical Name: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedion
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.

Compound Libraries

iCRT 14 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 375.44
Formula C21H17N3O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 677331-12-3
PubChem ID 5967294
InChI Key NCSHZXNGQYSKLR-UNOMPAQXSA-N
Smiles CC(N(C4=CN=CC=C4)C(C)=C3)=C3/C=C(SC2=O)/C(N2C1=CC=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.16 75
ethanol 1.88 5

Preparing Stock Solutions

The following data is based on the product molecular weight 375.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.32 mL 26.64 mL
5 mM 0.53 mL 2.66 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gonsalves et al (2011) An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc.Natl.Acad.Sci.USA 108 5954 PMID:

Watanabe and Dai (2011) Winning WNT: race to Wnt signaling inhibitors. Proc.Natl.Acad.Sci.USA 108 5929 PMID:


If you know of a relevant reference for iCRT 14, please let us know.

View Related Products by Target

Keywords: iCRT14 beta-catenin b-catenin β-catenin catenin-responsive transcription crt inhibitors inhibits wnt signaling signalling inhibitors inhibits TCF4 Beta-catenin

1 Citation for iCRT 14

Citations are publications that use Tocris products. Selected citations for iCRT 14 include:

Wu et al (2012) Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation. J Neurosci 32 6651 PMID: 22573687


Do you know of a great paper that uses iCRT 14 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for iCRT 14

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.

Protocols

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