Pricing Availability   Qty
Description: Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions
Purity: ≥95% (HPLC)
Pathways (1)

Biological Activity for NLS-StAx-h

NLS-StAx-h is a Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.

Technical Data for NLS-StAx-h

M. Wt 3445.26
Formula C161H275N55O29

(Modifications: Val-7 = Val-PEG2, Arg-8 = Arg-9 = Arg-12 = Arg-20 = Arg-21 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-24 = homo-Arg & C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2872559-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NLS-StAx-h

Solubility Soluble to 1 mg/ml in water

Product Datasheets for NLS-StAx-h

Certificate of Analysis / Product Datasheet
Select another batch:

References for NLS-StAx-h

References are publications that support the biological activity of the product.

Dietrich et al (2017) Cell permeable stapled peptide inhibitor of Wnt signaling that targets β-catenin protein-protein Interactions. Cell Chem.Biol. 24 958 PMID: 28757184

If you know of a relevant reference for NLS-StAx-h, please let us know.

View Related Products by Product Action

View all β-catenin Inhibitors

Keywords: NLS-StAx-h, NLS-StAx-h supplier, NLS, StAxh, StAx_h, Wnt, signaling, inhibitors, inhibits, beta, catenin, βcatenin, stapled, peptide, Beta-catenin, Stapled, Peptides, 6531, Tocris Bioscience

Citations for NLS-StAx-h

Citations are publications that use Tocris products.

Currently there are no citations for NLS-StAx-h. Do you know of a great paper that uses NLS-StAx-h from Tocris? Please let us know.

Reviews for NLS-StAx-h

There are currently no reviews for this product. Be the first to review NLS-StAx-h and earn rewards!

Have you used NLS-StAx-h?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for NLS-StAx-h

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.