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Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.
(Modifications: Val-7 = Val-PEG2, Arg-8 = homo-Arg, Arg-9 = homo-Arg, Arg-12 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-20 = homo-Arg, Arg-21 = homo-Arg, Arg-24 = homo-Arg;
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Dietrich et al (2017) Cell permeable stapled peptide inhibitor of Wnt signaling that targets beta -catenin protein-protein Interactions. Cell Chem.Biol. 24 958 PMID: 28757184
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Keywords: NLS-StAx-h, NLS-StAx-h supplier, NLS, StAxh, StAx_h, Wnt, signaling, inhibitors, inhibits, beta, catenin, βcatenin, stapled, peptide, Beta-catenin, Stapled, Peptides, 6531, Tocris Bioscience
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