NLS-StAx-h

Pricing Availability   Qty
Cat.No. 6531 - NLS-StAx-h | Pro-Lys-Lys-Lys-Arg-Lys-Val-PEG2-Har-Har-Trp-Pro-Har-[(S)-2-(4-pentenyl)alanine]-Ile-Leu-Asp-[(S)-2-(4-pentenyl)alanine]-His-Val-Har-Har-Val-Trp-Har-NH2 (double bond covalent bridge: X-13-X-17)
Description: Wnt signaling inhibitor
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.

Technical Data

M. Wt 3445.26
Formula C161H275N55O29
Sequence PKKKRKVRRWPRXILDXHVRRVWR

(Modifications: Val-7 = Val-PEG2, Arg-8 = homo-Arg, Arg-9 = homo-Arg, Arg-12 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-20 = homo-Arg, Arg-21 = homo-Arg, Arg-24 = homo-Arg;

Storage Store at -20°C
Smiles O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(NCCOCCOCC(N[C@@H](CCCCNC(N)=N)C(N[C@@H](CCCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N3[C@@H](CCC3)C(N[C@@H](CCCCNC(N)=N)C(N[C@@](C)(CCC/C=C\CCC[C@@](C(N[C@H](CC4=CNC=N4)C(N[C@H](C(C)C)C(N[C@H](CCCCNC(N)=N)C(N[C@H](CCCCNC(N)=N)C(N[C@H](C(C)C)C(N[C@H](CC5=CNC6=CC=CC=C56)C(N[C@H](CCCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)(C)N7)C(N[C@@H]([C@@H](C)CC)C(N[C@H](CC(C)C)C(N[C@H](CC(O)=O)C7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]8NCCC8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Dietrich et al (2017) Cell permeable stapled peptide inhibitor of Wnt signaling that targets beta -catenin protein-protein Interactions. Cell Chem.Biol. 24 958 PMID: 28757184


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Keywords: NLS-StAx-h, NLS-StAx-h supplier, NLS, StAxh, StAx_h, Wnt, signaling, inhibitors, inhibits, beta, catenin, βcatenin, Beta-catenin, 6531, Tocris Bioscience

Citations for NLS-StAx-h

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for NLS-StAx-h

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.