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Biological Activity for NLS-StAx-h
NLS-StAx-h is a Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.
Technical Data for NLS-StAx-h
(Modifications: Val-7 = Val-PEG2, Arg-8 = homo-Arg, Arg-9 = homo-Arg, Arg-12 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-20 = homo-Arg, Arg-21 = homo-Arg, Arg-24 = homo-Arg;
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NLS-StAx-h
|Solubility||Soluble to 1 mg/ml in water|
References for NLS-StAx-h
References are publications that support the biological activity of the product.
Dietrich et al (2017) Cell permeable stapled peptide inhibitor of Wnt signaling that targets beta -catenin protein-protein Interactions. Cell Chem.Biol. 24 958 PMID: 28757184
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Citations for NLS-StAx-h
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