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Description: N-WASP inhibitor; inhibits Arp2/3 activation
Chemical Name: 3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
Purity: ≥99% (HPLC)
Citations (3)

Biological Activity for Wiskostatin

Wiskostatin is an inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).

Compound Libraries for Wiskostatin

Wiskostatin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Wiskostatin

M. Wt 426.15
Formula C17H18Br2N2O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 253449-04-6
PubChem ID 2775510
Smiles BrC(C=C3)=CC1=C3N(CC(O)CN(C)C)C2=C1C=C(Br)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Wiskostatin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.62 100

Preparing Stock Solutions for Wiskostatin

The following data is based on the product molecular weight 426.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.73 mL 23.47 mL
5 mM 0.47 mL 2.35 mL 4.69 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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References for Wiskostatin

References are publications that support the biological activity of the product.

Wegner et al (2008) N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. J.Biol.Chem. 283 15912 PMID: 18430734

Peterson et al (2004) Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat.Struct.Mol.Biol. 11 747 PMID: 15235593

Guerriero and Weisz et al (2006) N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am.J.Physiol.Cell Physiol. 292 C1562 PMID: 17092993

If you know of a relevant reference for Wiskostatin, please let us know.

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Keywords: Wiskostatin, Wiskostatin supplier, Arp2/3, complex, n-wasp, wiskott-aldrich, syndrome, inhibitors, inhibits, actin, polymerization, 3,6-Dibromo-a-[(dimethylamino)methyl]-9H-cabazole-9-ethanol, Actin, 4434, Tocris Bioscience

3 Citations for Wiskostatin

Citations are publications that use Tocris products. Selected citations for Wiskostatin include:

Yogaditya et al (2021) A cryo-electron tomography workflow reveals protrusion-mediated shedding on injured plasma membrane. Sci Adv 7 PMID: 33771860

Rassokhin and Pakhomov (2014) Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF). Cell Biochem Biophys 69 555 PMID: 24488232

Raymond P et al (2022) Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model. J Virus Erad 8 100307 PMID: 36514715

Do you know of a great paper that uses Wiskostatin from Tocris? Please let us know.

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