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Biological Activity for Wiskostatin
Wiskostatin is an inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).
Compound Libraries for Wiskostatin
Technical Data for Wiskostatin
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Wiskostatin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Wiskostatin
The following data is based on the product molecular weight 426.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.35 mL||11.73 mL||23.47 mL|
|5 mM||0.47 mL||2.35 mL||4.69 mL|
|10 mM||0.23 mL||1.17 mL||2.35 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References for Wiskostatin
References are publications that support the biological activity of the product.
Wegner et al (2008) N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. J.Biol.Chem. 283 15912 PMID: 18430734
Peterson et al (2004) Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat.Struct.Mol.Biol. 11 747 PMID: 15235593
Guerriero and Weisz et al (2006) N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am.J.Physiol.Cell Physiol. 292 C1562 PMID: 17092993
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Keywords: Wiskostatin, Wiskostatin supplier, Arp2/3, complex, n-wasp, wiskott-aldrich, syndrome, inhibitors, inhibits, actin, polymerization, 3,6-Dibromo-a-[(dimethylamino)methyl]-9H-cabazole-9-ethanol, Actin, 4434, Tocris Bioscience
3 Citations for Wiskostatin
Citations are publications that use Tocris products. Selected citations for Wiskostatin include:
Yogaditya et al (2021) A cryo-electron tomography workflow reveals protrusion-mediated shedding on injured plasma membrane. Sci Adv 7 PMID: 33771860
Rassokhin and Pakhomov (2014) Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF). Cell Biochem Biophys 69 555 PMID: 24488232
Raymond P et al (2022) Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model. J Virus Erad 8 100307 PMID: 36514715
Do you know of a great paper that uses Wiskostatin from Tocris? Please let us know.
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Literature in this Area
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