Phalloidin

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Cat.No. 4535 - Phalloidin | Ala-D-Thr-Cys-Hyp-Ala-Trp-Leu (Modifications: Cyclic Cys-3-Trp-6) | CAS No. 17466-45-4
Description: Promotes actin polymerization
Datasheet
Citations
Literature

Biological Activity

Promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.

Technical Data

M. Wt 788.87
Formula C35H48N8O11S
Sequence ATCXAWL (Modifications: Cyclic Cys-3-Trp-6, X=Hyp, D-Thr-2)
Storage Store at -20°C
CAS Number 17466-45-4
PubChem ID 90488951
InChI Key KPKZJLCSROULON-RCGKFKHASA-N
Smiles O=C([C@H](N5)CSC(NC3=C2C=CC=C3)=C2C[C@@H](C(N[C@@H](C[C@](O)(C)CO)C(NC(C(N[C@H]([C@H](C)O)C5=O)=O)C)=O)=O)NC([C@@H](N[C@]4=O)C)=O)N1[C@H]4C[C@@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 788.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.27 mL 6.34 mL 12.68 mL
5 mM 0.25 mL 1.27 mL 2.54 mL
10 mM 0.13 mL 0.63 mL 1.27 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Diensthuber et al (2011) Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin. FEBS Lett. 585 767 PMID: 21295570

Cooper (1987) Effects of cytochalasin and phalloidin on actin. J.Cell Biol. 105 1473 PMID: 3312229

Coluccio and Tilney (1984) Phalloidin enhances actin assembly by preventing monomer dissociation. J.Cell Biol. 99 529 PMID: 6746738

Wehland et al (1977) Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. Proc.Natl.Acad.Sci.USA 74 5613 PMID: 341163


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Keywords: Phalloidin, supplier, actin, polymerization, polymerisation, promoters, Actin, Tocris Bioscience

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Cancer

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