Promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.
|Sequence||ATCXAWL (Modifications: Cyclic Cys-3-Trp-6, X=Hyp, D-Thr-2)|
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Diensthuber et al (2011) Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin. FEBS Lett. 585 767 PMID: 21295570
Cooper (1987) Effects of cytochalasin and phalloidin on actin. J.Cell Biol. 105 1473 PMID: 3312229
Coluccio and Tilney (1984) Phalloidin enhances actin assembly by preventing monomer dissociation. J.Cell Biol. 99 529 PMID: 6746738
Wehland et al (1977) Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. Proc.Natl.Acad.Sci.USA 74 5613 PMID: 341163
If you know of a relevant reference for Phalloidin, please let us know.
Keywords: Phalloidin, Phalloidin supplier, actin, polymerization, polymerisation, promoters, Actin, 4535, Tocris Bioscience
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