Phalloidin

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Description: Promotes actin polymerization
Purity: ≥90% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Phalloidin

Phalloidin is a promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.

Technical Data for Phalloidin

M. Wt 788.87
Formula C35H48N8O11S
Sequence ATCXAWL (Modifications: Cyclic Cys-3-Trp-6, X=Hyp, D-Thr-2)
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 17466-45-4
PubChem ID 90488951
InChI Key KPKZJLCSROULON-RCGKFKHASA-N
Smiles O=C([C@H](N5)CSC(NC3=C2C=CC=C3)=C2C[C@@H](C(N[C@@H](C[C@](O)(C)CO)C(NC(C(N[C@H]([C@H](C)O)C5=O)=O)C)=O)=O)NC([C@@H](N[C@]4=O)C)=O)N1[C@H]4C[C@@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Phalloidin

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Phalloidin

Certificate of Analysis / Product Datasheet
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References for Phalloidin

References are publications that support the biological activity of the product.

Diensthuber et al (2011) Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin. FEBS Lett. 585 767 PMID: 21295570

Cooper (1987) Effects of cytochalasin and phalloidin on actin. J.Cell Biol. 105 1473 PMID: 3312229

Coluccio and Tilney (1984) Phalloidin enhances actin assembly by preventing monomer dissociation. J.Cell Biol. 99 529 PMID: 6746738

Wehland et al (1977) Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. Proc.Natl.Acad.Sci.USA 74 5613 PMID: 341163


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Keywords: Phalloidin, Phalloidin supplier, actin, polymerization, polymerisation, promoters, Actin, 4535, Tocris Bioscience

1 Citation for Phalloidin

Citations are publications that use Tocris products. Selected citations for Phalloidin include:

Zhen et al (2009) Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex. J Neurosci 29 550-62 PMID: 19144855


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