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Cat.No. 2792 - Jasplakinolide | C36H45BrN4O6 | CAS No. 102396-24-7
Description: Stabilizes F-actin; promotes actin polymerization
Chemical Name: Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
Purity: ≥97% (HPLC)
Citations (5)

Biological Activity

Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

Technical Data

M. Wt 709.67
Formula C36H45BrN4O6
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 102396-24-7
PubChem ID 9831636
Smiles C[C@H](C[C@H](C)OC1=O)/C=C(C)/C[C@H](C)C(N[C@H](C(N([C@H](CC2=C(Br)NC3=C2C=CC=C3)C(N[C@@H]([C@]4=CC=C(O)C=C4)C1)=O)C)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2 3

Preparing Stock Solutions

The following data is based on the product molecular weight 709.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.41 mL 7.05 mL 14.09 mL
5 mM 0.28 mL 1.41 mL 2.82 mL
10 mM 0.14 mL 0.7 mL 1.41 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the biological activity of the product.

Cramer (1999) Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide. Curr.Biol. 9 1095 PMID: 10531004

Bubb et al (2000) Effects of jasplakinolide on the kinetics of actin polymerization. J.Biol.Chem. 275 5163 PMID: 10671562

Bubb et al (1995) Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J.Biol.Chem. 269 14869 PMID: 8195116

If you know of a relevant reference for Jasplakinolide, please let us know.

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Keywords: Jasplakinolide, Jasplakinolide supplier, actin, f-actin, monomers, polymerization, polymerisation, stabilizers, stabilizes, inducers, induces, polymers, Actin, 2792, Tocris Bioscience

5 Citations for Jasplakinolide

Citations are publications that use Tocris products. Selected citations for Jasplakinolide include:

Krawczyk et al (2015) Myocardin Family Members Drive Formation of Caveolae. PLoS One 10 e0133931 PMID: 26244347

LeClaire and Fortwendel (2015) Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins. PLoS One 10 e0142535 PMID: 26555617

Turczynska et al (2015) Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury. Cell 35 1489 PMID: 25857312

Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. PLoS One 160 673 PMID: 25679761

Galvez et al (2016) Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats. Neuropharmacology 105 378 PMID: 26867505

Do you know of a great paper that uses Jasplakinolide from Tocris? Please let us know.

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