Latrunculin B

Pricing Availability Delivery Time Qty
Cat.No. 3974 - Latrunculin B | C20H29NO5S | CAS No. 76343-94-7
Description: Inhibitor of actin polymerization
Chemical Name: (4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
Purity: ≥97% (HPLC)

Biological Activity

Inhibitor of actin polymerization. Interacts with G-actin in a 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively). Marine toxin.

Technical Data

M. Wt 395.51
Formula C20H29NO5S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 76343-94-7
PubChem ID 3892
Smiles O=C1/C=C(C)\CC/C=C\[C@@H](C)CC[C@@H]2C[C@H](C[C@](O)([C@@]3([H])NC(SC3)=O)O2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.78 50
ethanol 19.78 50

Preparing Stock Solutions

The following data is based on the product molecular weight 395.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.28 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Wakatsuki et al (2001) Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J.Cell.Sci. 114 1025 PMID: 11181185

If you know of a relevant reference for Latrunculin B, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Actin Inhibitors

Keywords: Latrunculin B, supplier, Inhibitors, Inhibits, Actin, filament, modulator, G-Actin, F-Actin, monomers, polymers, toxin, Actin, Actin, Tocris Bioscience

Citations for Latrunculin B

Citations are publications that use Tocris products.

Currently there are no citations for Latrunculin B. Do you know of a great paper that uses Latrunculin B from Tocris? If so please let us know.

Latrunculin B Reviews

Average Rating:

(Based on 0 Reviews)

1 Star
2 Star
3 Star
4 Star
5 Star

Have you used Latrunculin B?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis