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Submit ReviewLatrunculin B
Description: Inhibitor of actin polymerization
Chemical Name: (4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
Purity: ≥95% (HPLC)
Biological Activity for Latrunculin B
Latrunculin B is an inhibitor of actin polymerization. Interacts with G-actin in a 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively). Marine toxin.
Technical Data for Latrunculin B
| M. Wt | 395.51 |
| Formula | C20H29NO5S |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 76343-94-7 |
| PubChem ID | 3892 |
| InChI Key | NSHPHXHGRHSMIK-UHFFFAOYSA-N |
| Smiles | O=C1/C=C(C)\CC/C=C\[C@@H](C)CC[C@@H]2C[C@H](C[C@](O)([C@@]3([H])NC(SC3)=O)O2)O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Latrunculin B
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.78 | 50 | |
| ethanol | 19.78 | 50 |
Preparing Stock Solutions for Latrunculin B
The following data is based on the product molecular weight 395.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.06 mL | 25.28 mL | 50.57 mL |
| 2.5 mM | 1.01 mL | 5.06 mL | 10.11 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 25 mM | 0.1 mL | 0.51 mL | 1.01 mL |
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Product Datasheets for Latrunculin B
References for Latrunculin B
References are publications that support the biological activity of the product.
Wakatsuki et al (2001) Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J.Cell.Sci. 114 1025 PMID: 11181185
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Keywords: Latrunculin B, Latrunculin B supplier, Inhibitors, Inhibits, Actin, filament, modulator, G-Actin, F-Actin, monomers, polymers, toxin, 3974, Tocris Bioscience
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