Latrunculin B

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Description: Inhibitor of actin polymerization
Chemical Name: (4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
Purity: ≥95% (HPLC)
Citations (5)

Biological Activity for Latrunculin B

Latrunculin B is an inhibitor of actin polymerization. Interacts with G-actin in a 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively). Marine toxin.

Technical Data for Latrunculin B

M. Wt 395.51
Formula C20H29NO5S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 76343-94-7
PubChem ID 3892
Smiles O=C1/C=C(C)\CC/C=C\[C@@H](C)CC[C@@H]2C[C@H](C[C@](O)([C@@]3([H])NC(SC3)=O)O2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Latrunculin B

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.78 50
ethanol 19.78 50

Preparing Stock Solutions for Latrunculin B

The following data is based on the product molecular weight 395.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.06 mL 25.28 mL 50.57 mL
2.5 mM 1.01 mL 5.06 mL 10.11 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
25 mM 0.1 mL 0.51 mL 1.01 mL

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Product Datasheets for Latrunculin B

Certificate of Analysis / Product Datasheet
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References for Latrunculin B

References are publications that support the biological activity of the product.

Wakatsuki et al (2001) Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J.Cell.Sci. 114 1025 PMID: 11181185

If you know of a relevant reference for Latrunculin B, please let us know.

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Keywords: Latrunculin B, Latrunculin B supplier, Inhibitors, Inhibits, Actin, filament, modulator, G-Actin, F-Actin, monomers, polymers, toxin, 3974, Tocris Bioscience

5 Citations for Latrunculin B

Citations are publications that use Tocris products. Selected citations for Latrunculin B include:

Mart et al (2019) Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle. Mol Cell 75 76-89.e3 PMID: 31101497

Zheng et al (2019) A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport. Cell Rep 28 3224-3237.e5 PMID: 31533043

Verónica et al (2020) Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications. Am J Physiol Cell Physiol 318 C282-C288 PMID: 31747316

Ying et al (2020) MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis. Nat Commun 11 3151 PMID: 32561730

Do you know of a great paper that uses Latrunculin B from Tocris? Please let us know.

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