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Biological Activity for Cytochalasin B
Cytochalasin B is an inhibitor of actin polymerization. Inhibits cell division, migration and glucose transport. Causes G2/M cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma cells. Cell permeable.
Technical Data for Cytochalasin B
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cytochalasin B
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.8||10 with gentle warming|
Preparing Stock Solutions for Cytochalasin B
The following data is based on the product molecular weight 479.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.43 mL||52.13 mL||104.25 mL|
|1 mM||2.09 mL||10.43 mL||20.85 mL|
|2 mM||1.04 mL||5.21 mL||10.43 mL|
|10 mM||0.21 mL||1.04 mL||2.09 mL|
References for Cytochalasin B
References are publications that support the biological activity of the product.
Theodoropoulos et al (1994) Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochem.Pharmacol. 47 1875 PMID: 8204105
Whitesell et al (2005) Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line. Biochem.J. 386 245 PMID: 15473866
Buldak et al (2014) Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment. Eur.J.Histochem. 58 2408 PMID: 25308845
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Keywords: Cytochalasin B, Cytochalasin B supplier, inhibitors, inhibits, actin, polymerization, polymerisation, cell, permeable, division, migration, cycle, arrest, cytokinesis, Actin, 5474, Tocris Bioscience
2 Citations for Cytochalasin B
Citations are publications that use Tocris products. Selected citations for Cytochalasin B include:
Bernier et al (2019) Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia. Cell Rep 27 2895 PMID: 31167136
Diaz-Garcia et al (2017) Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake. Cell Metab 26 361 PMID: 28768175
Do you know of a great paper that uses Cytochalasin B from Tocris? Please let us know.
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Literature in this Area
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