Cytochalasin B

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Description: Inhibitor of actin polymerization
Chemical Name: (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews

Biological Activity for Cytochalasin B

Cytochalasin B is an inhibitor of actin polymerization. Inhibits cell division, migration and glucose transport. Causes G2/M cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma cells. Cell permeable.

Technical Data for Cytochalasin B

M. Wt 479.61
Formula C29H37NO5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 14930-96-2
PubChem ID 5311281
InChI Key GBOGMAARMMDZGR-TYHYBEHESA-N
Smiles C=C([C@H]1C)[C@@H](O)[C@]([C@@]2(O3)[C@]1([H])[C@H](CC4=CC=CC=C4)NC2=O)([H])/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cytochalasin B

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.8 10 with gentle warming

Preparing Stock Solutions for Cytochalasin B

The following data is based on the product molecular weight 479.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.85 mL 104.25 mL 208.5 mL
0.5 mM 4.17 mL 20.85 mL 41.7 mL
1 mM 2.09 mL 10.43 mL 20.85 mL
5 mM 0.42 mL 2.09 mL 4.17 mL

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Product Datasheets for Cytochalasin B

Certificate of Analysis / Product Datasheet
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References for Cytochalasin B

References are publications that support the biological activity of the product.

Theodoropoulos et al (1994) Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochem.Pharmacol. 47 1875 PMID: 8204105

Whitesell et al (2005) Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line. Biochem.J. 386 245 PMID: 15473866

Buldak et al (2014) Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment. Eur.J.Histochem. 58 2408 PMID: 25308845


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Keywords: Cytochalasin B, Cytochalasin B supplier, inhibitors, inhibits, actin, polymerization, polymerisation, cell, permeable, division, migration, cycle, arrest, cytokinesis, Actin, 5474, Tocris Bioscience

7 Citations for Cytochalasin B

Citations are publications that use Tocris products. Selected citations for Cytochalasin B include:

Maria F et al (2021) ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells. Elife 10 PMID: 34169836

Bernier et al (2019) Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia. Cell Rep 27 2895 PMID: 31167136

David Ian et al (2022) Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances. Arch Toxicol 96 1455-1471 PMID: 35226136

Ingrid et al (2022) WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues. Dev Cell 57 47-62.e9 PMID: 34919802


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