Latrunculin A

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Cat.No. 3973 - Latrunculin A | C22H31NO5S | CAS No. 76343-93-6
Description: Inhibitor of actin assembly and polymerization
Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
Purity: ≥95% (HPLC)
Citations (19)
Literature (1)

Biological Activity for Latrunculin A

Latrunculin A is a reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.

This product is typically reconstituted in DMSO as a primary solvent.

Technical Data for Latrunculin A

M. Wt 421.55
Formula C22H31NO5S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 76343-93-6
PubChem ID 445420
Smiles C[C@@H](CC[C@]2([H])C[C@@](C[C@](O)([C@]3([H])CSC(N3)=O)O2)([H])O1)\C=C/C=C/CC/C(C)=C\C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Latrunculin A

Certificate of Analysis / Product Datasheet
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References for Latrunculin A

References are publications that support the biological activity of the product.

Yarmola et al (2000) Actin-latrunculin A structure and function. J.Biol.Chem. 275 28120 PMID: 10859320

Morton et al (2000) Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat.Cell Biol. 2 376 PMID: 10854330

Blasberger et al (1989) On the chemistry of latrunculins A and B. Liebigs.Ann.Chem. 1989 1171

If you know of a relevant reference for Latrunculin A, please let us know.

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Keywords: Latrunculin A, Latrunculin A supplier, inhibits, inhibitors, actin, assembly, polymerization, polymerisation, LatrunculinA, Actin, 3973, Tocris Bioscience

19 Citations for Latrunculin A

Citations are publications that use Tocris products. Selected citations for Latrunculin A include:

Tazerart et al (2020) A spike-timing-dependent plasticity rule for dendritic spines. Nat Commun 11 4276 PMID: 32848151

Haag et al (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep 24 2418 PMID: 30157434

Lettau et al (2018) Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells. Int Immunol 30 215 PMID: 29373679

Neumann et al (2018) Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation. Dev Cell 45 67 PMID: 29634937

Han et al (2016) Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation Nature 539 570 PMID: 27820945

Koopmans et al (2016) Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction. Sci Rep 6 30676 PMID: 27468699

Lim et al (2019) Identification of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun 10 1547 PMID: 30948712

Arash et al (2014) Arhgef7 promotes activation of the Hippo pathway core kinase Lats. EMBO J 33 2997 PMID: 25425573

Kawashima et al (2012) Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology. Chem Biol 19 893 PMID: 22840777

Lionarons et al (2019) RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell 36 68 PMID: 31257073

Hubaud et al (2017) Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock. Cell 171 668 PMID: 28942924

Suzuki et al (2015) Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology. Neuron 5 16874 PMID: 26575097

Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One 85 173 PMID: 25569349

Davies et al (2018) Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity. Elife 7 PMID: 30028292

Wisdom et al (2018) Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments. Nat Commun 9 4144 PMID: 30297715

Dalton and Carroll (2013) Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte. J Cell Sci 126 2955 PMID: 23659999

Oenema et al (2016) Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. Oncotarget 8 e65580 PMID: 23840342

Saba et al (2014) Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication. Am J Respir Cell Mol Biol 50 974 PMID: 24783958

Petrosyan et al (2016) The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization. Sci Rep 6 31962 PMID: 27535804

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Literature in this Area

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