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Reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 421.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||23.72 mL||118.61 mL||237.22 mL|
|0.5 mM||4.74 mL||23.72 mL||47.44 mL|
|1 mM||2.37 mL||11.86 mL||23.72 mL|
|5 mM||0.47 mL||2.37 mL||4.74 mL|
References are publications that support the biological activity of the product.
Yarmola et al (2000) Actin-latrunculin A structure and function. J.Biol.Chem. 275 28120 PMID: 10859320
Morton et al (2000) Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat.Cell Biol. 2 376 PMID: 10854330
Blasberger et al (1989) On the chemistry of latrunculins A and B. Liebigs.Ann.Chem. 1989 1171
If you know of a relevant reference for Latrunculin A, please let us know.
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Keywords: Latrunculin A, Latrunculin A supplier, inhibits, inhibitors, actin, assembly, polymerization, polymerisation, LatrunculinA, Actin, 3973, Tocris Bioscience
19 Citations for Latrunculin A
Citations are publications that use Tocris products. Selected citations for Latrunculin A include:
Koopmans et al (2016) Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction. Sci Rep 6 30676 PMID: 27468699
Lionarons et al (2019) RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell 36 68 PMID: 31257073
Arash et al (2014) Arhgef7 promotes activation of the Hippo pathway core kinase Lats. EMBO J 33 2997 PMID: 25425573
Kawashima et al (2012) Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology. Chem Biol 19 893 PMID: 22840777
Lim et al (2019) Identification of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun 10 1547 PMID: 30948712
Tazerart et al (2019) Spike-timing-dependent plasticity rule for single, clustered and distributed dendritic spines BioRXiv
Hubaud et al (2017) Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock. Cell 171 668 PMID: 28942924
Suzuki et al (2015) Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology. Neuron 5 16874 PMID: 26575097
Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One 85 173 PMID: 25569349
Davies et al (2018) Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity. Elife 7 PMID: 30028292
Wisdom et al (2018) Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments. Nat Commun 9 4144 PMID: 30297715
Dalton and Carroll (2013) Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte. J Cell Sci 126 2955 PMID: 23659999
Oenema et al (2016) Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. Oncotarget 8 e65580 PMID: 23840342
Saba et al (2014) Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication. Am J Respir Cell Mol Biol 50 974 PMID: 24783958
Petrosyan et al (2016) The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization. Sci Rep 6 31962 PMID: 27535804
Han et al (2016) Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation Nature 539 570 PMID: 27820945
Neumann et al (2018) Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation. Dev Cell 45 67 PMID: 29634937
Haag et al (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep 24 2418 PMID: 30157434
Lettau et al (2018) Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells. Int Immunol 30 215 PMID: 29373679
Do you know of a great paper that uses Latrunculin A from Tocris? Please let us know.
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Literature in this Area
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