CK 666

Pricing Availability Delivery Time Qty
Cat.No. 3950 - CK 666 | C18H17FN2O | CAS No. 442633-00-3
Description: Arp2/3 inhibitor; inhibits actin polymerization
Chemical Name: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Literature

Biological Activity

Inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC50 = 4 μM).

Technical Data

M. Wt 296.34
Formula C18H17FN2O
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 442633-00-3
PubChem ID 589075
InChI Key UXRKUKRXVWJFER-UHFFFAOYSA-N
Smiles FC1=CC=CC=C1C(NCCC2=C(C)NC3=C2C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.63 100
ethanol 29.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 296.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.75 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nolen et al (2009) Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460 1031 PMID: 19648907

Han and Nolen (2009) X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors. 1751 ACSB 2009 Abstracts. American Society for Cel PMID:


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View all Actin Inhibitors

Keywords: CK666 arp2/3 actin polymerization inhibitors inhibits actin-related proteins arp2 arp3 Actin

6 Citations for CK 666

Citations are publications that use Tocris products. Selected citations for CK 666 include:

Bharadwaj (2017) αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun 8 14348 PMID: 28128308

Han et al (2016) Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation Nature 539 570 PMID: 27820945

Tornavaca et al (2015) ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. Proc Natl Acad Sci U S A 208 821 PMID: 25753039

Moreau et al (2015) Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest. Nat Commun 112 12151 PMID: 26371316

Sorce et al (2015) Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement. Cell Calcium 6 8872 PMID: 26602832

Dalton and Carroll (2013) Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte. J Cell Sci 126 2955 PMID: 23659999


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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for CK 666

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