Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
CK 666 is an inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC50 = 4 μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 296.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.37 mL||16.87 mL||33.75 mL|
|5 mM||0.67 mL||3.37 mL||6.75 mL|
|10 mM||0.34 mL||1.69 mL||3.37 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
References are publications that support the biological activity of the product.
Nolen et al (2009) Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460 1031 PMID: 19648907
Han and Nolen (2009) X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors. 1751 ACSB 2009 Abstracts. American Society for Cel
If you know of a relevant reference for CK 666, please let us know.
Keywords: CK 666, CK 666 supplier, CK666, arp2/3, actin, polymerization, inhibitors, inhibits, actin-related, proteins, arp2, arp3, Actin, 3950, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for CK 666 include:
Han et al (2016) Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation Nature 539 570 PMID: 27820945
Sepúlveda-Ramírez et al (2018) Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo. Dev Biol 437 140 PMID: 29555242
Yamagashi et al (2018) Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun 496 834 PMID: 29395083
Panousopoulou et al (2016) Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body. J Cell Sci 129 1915 PMID: 26989131
Roesler et al (2019) Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization. Front Cell Neurosci 13 330 PMID: 31474830
Bharadwaj (2017) αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun 8 14348 PMID: 28128308
Logue et al (2018) c-Src activity is differentially required by cancer cell motility modes. Oncogene 37 2104 PMID: 29379163
Tabdanov et al (2018) Bimodal sensing of guidance cues in mechanically distinct microenvironments. Nat Commun 9 4891 PMID: 30459308
Tabdanov et al (2018) Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing. Cell Rep 25 328 PMID: 30304674
Tornavaca et al (2015) ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. Proc Natl Acad Sci U S A 208 821 PMID: 25753039
Moreau et al (2015) Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest. Nat Commun 112 12151 PMID: 26371316
Sorce et al (2015) Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement. Cell Calcium 6 8872 PMID: 26602832
Dalton and Carroll (2013) Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte. J Cell Sci 126 2955 PMID: 23659999
Basu et al (2016) Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala. Eneuro 3 PMID: 27957528
Do you know of a great paper that uses CK 666 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review CK 666 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.