TRPM

The melastatin-related receptor family (TRPM) is the largest subfamily of the transient receptor potential (TRP) superfamily of ion channels. It contains 8 known members, subdivided into 4 groups, which perform a range of functions including detection of taste and osmolarity.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
5521 CIM 0216
Selective TRPM3 agonist
1531 Icilin
Activates a novel cold receptor. Cooling agent
3040 WS 12
TRPM8 agonist; cooling agent
2927 WS 3
TRPM8 agonist; cooling agent

Antagonists

Cat No Product Name / Activity
5388 RQ 00203078
Potent and selective TRPM8 antagonist; orally active
5410 TC-I 2014
Potent TRPM8 antagonist

Activators

Cat No Product Name / Activity
5376 Pregnenolone sulfate sodium salt
NMDA Potentiator; activates TRPM3 channels

Blockers

Cat No Product Name / Activity
3989 AMTB hydrochloride
TRPM8 blocker
5324 M8 B hydrochloride
Potent and selective TRPM8 channel blocker
5143 Ononetin
TRPM3 blocker
6003 PF 05105679
Selective TRPM8 blocker
4999 9-Phenanthrol
Selective TRPM4 blocker
4632 TC-I 2000
TRPM8 blocker

Other

Cat No Product Name / Activity
1268 U 73122
TRPM4 activator and TRPM3 blocker; also phospholipase C inhibitor

The melastatin-related receptor family (TRPM) is the largest subfamily of the transient receptor potential (TRP) superfamily of ion channels. It contains 8 known members, subdivided into 4 groups, which perform a range of functions including detection of taste and osmolarity, and control of cell proliferation.

Members of the TRPM subfamily are grouped on the basis of sequence homology. The first subgroup includes TRPM1 and TRPM3; the second, TRPM6 and TRPM7; the third, TRPM2 and TRPM8; and the fourth, TRPM4 and TRPM5. TRPM channels are involved in a range of cellular processes, including insulin secretion (TRPM2, TRPM4), Mg2+ homeostasis (TRPM6, TRPM7), and cold signaling (TRPM8). TRPM8 is also known as CMR1 (cold and menthol receptor 1) due to its interaction with menthol.

TRPM channels play an important role in numerous vascular processes - including mechanosensory transduction and vascular inflammation - and such properties could make TRPM channels key therapeutic targets for the treatment of vascular disease.

External sources of pharmacological information for TRPM :

Literature for TRPM

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

TRPM Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TRPM1 Human TRPM1 NM_002420 AF071787
Mouse Trpm1 NM_018752 Q2TV84
Rat Trpm1 NM_001037734 Q2WEA5
TRPM2 Human TRPM2 NM_003307 AB001535
Mouse Trpm2 NM_138301 Q91YD4
Rat Trpm2 NM_001011559 Q5G856
TRPM3 Human TRPM3 NM_206945 AB046836
Mouse Trpm3 NM_001035239 Q5F4S9
TRPM4 Human TRPM4 NM_017636 AK000048
Mouse Trpm4 NM_175130 Q7TN37
Rat Trpm4 NM_001136229 Q9ESQ5
TRPM5 Human TRPM5 NM_014555 AF177473
Mouse Trpm5 NM_020277 Q9JJH7
TRPM6 Human TRPM6 NM_017662 AK026281
Mouse Trpm6 NM_153417 Q8CIR4
TRPM7 Human TRPM7 NM_017672 AF346629
Mouse Trpm7 NM_021450 Q923J1
TRPM8 Human TRPM8 NM_024080 AC005538
Mouse Trpm8 NM_134252 Q8R4D5
Rat Trpm8 NM_134371 Q8R455