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Selective TRPM3 agonist. Exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. Stimulates insulin release from pancreatic islet cells in vitro. Evokes nocifensive behavior in mice.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.88 mL||14.39 mL||28.78 mL|
|5 mM||0.58 mL||2.88 mL||5.76 mL|
|10 mM||0.29 mL||1.44 mL||2.88 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References are publications that support the biological activity of the product.
Held et al (2015) Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc.Natl.Acad.Sci.U.S.A. 112 E1363 PMID: 25733887
If you know of a relevant reference for CIM 0216, please let us know.
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Keywords: CIM 0216, CIM 0216 supplier, CIM0216, TRPM3, transient, potential, membrane, ion, channels, pain, insulin, TRPM, 5521, Tocris Bioscience
1 Citation for CIM 0216
Citations are publications that use Tocris products. Selected citations for CIM 0216 include:
Rubil and Thiel (2017) Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels. Channels (Austin) 11 79 PMID: 27356187
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.