CIM 0216

Pricing Availability   Qty
Description: Selective TRPM3 agonist
Chemical Name: 3,4-Dihydro-N-(5-methyl-3-isoxazolyl)-α-phenyl-1(2H)-quinolineacetamide
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for CIM 0216

CIM 0216 is a selective TRPM3 agonist. Exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. Stimulates insulin release from pancreatic islet cells in vitro. Evokes nocifensive behavior in mice.

Compound Libraries for CIM 0216

CIM 0216 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CIM 0216

M. Wt 347.41
Formula C21H21N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1031496-06-6
PubChem ID 42887770
Smiles O=C(NC1=NOC(C)=C1)C(C2=CC=CC=C2)N(CCC3)C4=C3C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CIM 0216

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.74 100
ethanol 17.37 50

Preparing Stock Solutions for CIM 0216

The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.78 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for CIM 0216

References are publications that support the biological activity of the product.

Held et al (2015) Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc.Natl.Acad.Sci.U.S.A. 112 E1363 PMID: 25733887

If you know of a relevant reference for CIM 0216, please let us know.

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Keywords: CIM 0216, CIM 0216 supplier, CIM0216, TRPM3, transient, potential, membrane, ion, channels, pain, insulin, TRPM, 5521, Tocris Bioscience

2 Citations for CIM 0216

Citations are publications that use Tocris products. Selected citations for CIM 0216 include:

Xi et al (2021) ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. Nat Commun 12 1401 PMID: 33658516

Rubil and Thiel (2017) Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels. Channels (Austin) 11 79 PMID: 27356187

Do you know of a great paper that uses CIM 0216 from Tocris? Please let us know.

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