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Biological Activity for CIM 0216
CIM 0216 is a selective TRPM3 agonist. Exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. Stimulates insulin release from pancreatic islet cells in vitro. Evokes nocifensive behavior in mice.
Compound Libraries for CIM 0216
Technical Data for CIM 0216
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CIM 0216
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CIM 0216
The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.88 mL||14.39 mL||28.78 mL|
|5 mM||0.58 mL||2.88 mL||5.76 mL|
|10 mM||0.29 mL||1.44 mL||2.88 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References for CIM 0216
References are publications that support the biological activity of the product.
Held et al (2015) Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc.Natl.Acad.Sci.U.S.A. 112 E1363 PMID: 25733887
If you know of a relevant reference for CIM 0216, please let us know.
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Keywords: CIM 0216, CIM 0216 supplier, CIM0216, TRPM3, transient, potential, membrane, ion, channels, pain, insulin, TRPM, 5521, Tocris Bioscience
2 Citations for CIM 0216
Citations are publications that use Tocris products. Selected citations for CIM 0216 include:
Xi et al (2021) ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. Nat Commun 12 1401 PMID: 33658516
Rubil and Thiel (2017) Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels. Channels (Austin) 11 79 PMID: 27356187
Do you know of a great paper that uses CIM 0216 from Tocris? Please let us know.
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