Pregnenolone sulfate sodium salt

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Cat.No. 5376 - Pregnenolone sulfate sodium salt | C21H31NaO5S | CAS No. 1852-38-6
Description: NMDA potentiator; also GABAA inhibitor and TRPM3 activator
Chemical Name: (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Highly potent neurosteroid with multiple actions. Enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 ~ 2 pM) and potentiates NMDA responses. Inhibitor at GABAA receptors (IC50 values are 0.4 to >300 μM, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.

Technical Data

M. Wt 418.52
Formula C21H31NaO5S
Storage Store at +4°C
CAS Number 1852-38-6
PubChem ID 23676306
InChI Key QQVJEIZJHDPTSH-UTNKIXDHSA-M
Smiles O=[C@](C)[C@H]4CC[C@@]3([H])[C@]2([H])CC=C1C[C@@H](OS(=O)([O-])=O)CC[C@@](C)1[C@]([H])2CC[C@@]34C.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.19 10 with sonication
DMSO 41.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 418.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.95 mL 23.89 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References

References are publications that support the biological activity of the product.

Li et al (2007) Neuroactive steroids and human recombinant rho1 GABAC receptors. J.Pharmacol.Exp.Ther. 323 236 PMID: 17636008

Majeed et al (2010) Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br.J.Pharmacol. 161 430 PMID: 20735426

Smith et al (2014) A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol.Pharmacol. 86 390 PMID: 25057049

Seljeset et al (2018) Probing GABAA receptors with inhibitory neurosteroids. Neuropharmacology 136 23 PMID: 29447845


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Keywords: Pregnenolone sulfate sodium salt, Pregnenolone sulfate sodium salt supplier, neuroactive, steroids, highly, potent, NMDA, TRPM3, memory, LTP, potentiators, activates, activators, GABA, Receptors, TRPM, GABAA, 5376, Tocris Bioscience

1 Citation for Pregnenolone sulfate sodium salt

Citations are publications that use Tocris products. Selected citations for Pregnenolone sulfate sodium salt include:

Luoma et al (2011) Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids 76 845 PMID: 21371490


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