Ononetin

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Cat.No. 5143 - Ononetin | C15H14O4 | CAS No. 487-49-0
Description: TRPM3 blocker
Chemical Name: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Naturally occurring deoxybenzoin. TRPM3 channel blocker (IC50 = 300 nM). Inhibits pregnenolone sulfate-induced intracellular Ca2+ accumulation in HEKmTRPM3 cells and dorsal root ganglia (DRG) neurons in vitro.

Technical Data

M. Wt 258.27
Formula C15H14O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 487-49-0
PubChem ID 259632
InChI Key XHBZOAYMBBUURD-UHFFFAOYSA-N
Smiles COC1=CC=C(CC(C2=C(O)C=C(O)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.83 100
ethanol 25.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 258.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.87 mL 19.36 mL 38.72 mL
5 mM 0.77 mL 3.87 mL 7.74 mL
10 mM 0.39 mL 1.94 mL 3.87 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Straub et al (2012) Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br.J.Pharmacol. 168 1835 PMID: 23190005


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Keywords: TRPM3 blockers transient receptor potential channels TRPM

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Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for Ononetin

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