Ononetin

Pricing Availability   Qty
Cat.No. 5143 - Ononetin | C15H14O4 | CAS No. 487-49-0
Description: TRPM3 blocker
Chemical Name: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Naturally occurring deoxybenzoin. TRPM3 channel blocker (IC50 = 300 nM). Inhibits pregnenolone sulfate-induced intracellular Ca2+ accumulation in HEKmTRPM3 cells and dorsal root ganglia (DRG) neurons in vitro.

Technical Data

M. Wt 258.27
Formula C15H14O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 487-49-0
PubChem ID 259632
InChI Key XHBZOAYMBBUURD-UHFFFAOYSA-N
Smiles COC1=CC=C(CC(C2=C(O)C=C(O)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.83 100
ethanol 25.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 258.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.87 mL 19.36 mL 38.72 mL
5 mM 0.77 mL 3.87 mL 7.74 mL
10 mM 0.39 mL 1.94 mL 3.87 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Straub et al (2012) Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br.J.Pharmacol. 168 1835 PMID: 23190005


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Keywords: Ononetin, Ononetin supplier, TRPM3, blockers, transient, receptor, potential, channels, TRPM, 5143, Tocris Bioscience

1 Citation for Ononetin

Citations are publications that use Tocris products. Selected citations for Ononetin include:

Son et al (2015) Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. J Dent Res 94 473 PMID: 25595364


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Literature in this Area

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