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Description: TRPM3 blocker
Chemical Name: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
Purity: ≥98% (HPLC)
Biological Activity
Naturally occurring deoxybenzoin. TRPM3 channel blocker (IC50 = 300 nM). Inhibits pregnenolone sulfate-induced intracellular Ca2+ accumulation in HEKmTRPM3 cells and dorsal root ganglia (DRG) neurons in vitro.
Technical Data
| M. Wt | 258.27 |
| Formula | C15H14O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 487-49-0 |
| PubChem ID | 259632 |
| InChI Key | XHBZOAYMBBUURD-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(CC(C2=C(O)C=C(O)C=C2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.83 | 100 | |
| ethanol | 25.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 258.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.87 mL | 19.36 mL | 38.72 mL |
| 5 mM | 0.77 mL | 3.87 mL | 7.74 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.87 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Straub et al (2012) Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br.J.Pharmacol. 168 1835 PMID: 23190005
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Keywords: Ononetin, Ononetin supplier, TRPM3, blockers, transient, receptor, potential, channels, TRPM, 5143, Tocris Bioscience
1 Citation for Ononetin
Citations are publications that use Tocris products. Selected citations for Ononetin include:
Son et al (2015) Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. J Dent Res 94 473 PMID: 25595364
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Pain Research Product GuideUpdated
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.