M8 B hydrochloride

Pricing Availability   Qty
Description: Potent and selective TRPM8 channel blocker
Chemical Name: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for M8 B hydrochloride

M8 B hydrochloride is a potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC50 values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC50 > 20 μM). Reduces body temperature in vivo.

Compound Libraries for M8 B hydrochloride

M8 B hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for M8 B hydrochloride

M. Wt 432.96
Formula C22H24N2O3S.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 883976-12-3
PubChem ID 69316632
InChI Key FMQJBHACRTZLME-UHFFFAOYSA-N
Smiles COC1=C(OCC2=CC=CC=C2)C=CC(CN(CCN)C(C3=CC=CS3)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for M8 B hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.33 10 with sonication
DMSO 43.3 100

Preparing Stock Solutions for M8 B hydrochloride

The following data is based on the product molecular weight 432.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.55 mL 23.1 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets for M8 B hydrochloride

References for M8 B hydrochloride

References are publications that support the biological activity of the product.

Almeida et al (2012) Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci. 32 2086 PMID: 22323721


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Citations for M8 B hydrochloride

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