M8 B hydrochloride

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Cat.No. 5324 - M8 B hydrochloride | C22H24N2O3S.HCl | CAS No. 883976-12-3
Description: Potent and selective TRPM8 channel blocker
Chemical Name: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC50 values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC50 > 20 μM). Reduces body temperature in vivo.

Compound Libraries

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Technical Data

M. Wt 432.96
Formula C22H24N2O3S.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 883976-12-3
PubChem ID 69316632
InChI Key FMQJBHACRTZLME-UHFFFAOYSA-N
Smiles COC1=C(OCC2=CC=CC=C2)C=CC(CN(CCN)C(C3=CC=CS3)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.33 10 with sonication
DMSO 43.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 432.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.55 mL 23.1 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Almeida et al (2012) Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci. 32 2086 PMID: 22323721


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