TC-I 2000

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Cat.No. 4632 - TC-I 2000 | CAS No. 1159996-20-9
Description: TRPM8 blocker
Chemical Name: N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM).

Compound Libraries

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Technical Data

M. Wt 414.4
Formula C23H18F4N2O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1159996-20-9
PubChem ID 57326210
InChI Key ADCDUDFEGFKKQH-UHFFFAOYSA-N
Smiles O=C(NC3=CC=C(F)C=C3)N2C(C4=CC=C(C(F)(F)F)C=C4)C1=CC=CC=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.44 100
ethanol 8.29 20

Preparing Stock Solutions

The following data is based on the product molecular weight 414.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.07 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tamayo et al (2012) Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. J.Med.Chem. 55 1593 PMID: 22329507


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Keywords: TC-I 2000, supplier, TCI2000, TRPM8, transient, receptor, potential, channels, blockers, TRPM, TRPM, Tocris Bioscience

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Literature in this Area

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