TC-I 2000

Pricing Availability   Qty
Description: TRPM8 blocker
Chemical Name: N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide
Purity: ≥99% (HPLC)

Biological Activity for TC-I 2000

TC-I 2000 is a tRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM).

Compound Libraries for TC-I 2000

TC-I 2000 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-I 2000

M. Wt 414.4
Formula C23H18F4N2O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1159996-20-9
PubChem ID 57326210
Smiles O=C(NC3=CC=C(F)C=C3)N2C(C4=CC=C(C(F)(F)F)C=C4)C1=CC=CC=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-I 2000

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.44 100
ethanol 8.29 20

Preparing Stock Solutions for TC-I 2000

The following data is based on the product molecular weight 414.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.07 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for TC-I 2000

References are publications that support the biological activity of the product.

Tamayo et al (2012) Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. J.Med.Chem. 55 1593 PMID: 22329507

If you know of a relevant reference for TC-I 2000, please let us know.

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Keywords: TC-I 2000, TC-I 2000 supplier, TCI2000, TRPM8, transient, receptor, potential, channels, blockers, TRPM, 4632, Tocris Bioscience

Citations for TC-I 2000

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