TRPA1

The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer.

Products
Background
Gene Data

TRPA1 Activators

Cat. No. Product Name / Activity
5178 ASP 7663
Selective TRPA1 activator
1531 Icilin
Activates cold receptors. Cooling agent
6269 JT010
Potent and selective TRPA1 channel activator
3197 Polygodial
TRPA1 channel activator; analgesic and antifungal
1418 Resveratrol
TRPA1 activator: also cyclooxygenase inhibitor

TRPA1 Blockers

Cat. No. Product Name / Activity
4716 A 967079
Selective TRPA1 channel blocker
5914 AM 0902
Potent and selective TRPA1 antagonist
3296 AP 18
Reversible TRPA1 channel blocker
2896 HC 030031
Selective TRPA1 blocker

The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer. This channel is thought to be indirectly activated by cold; it is often expressed in the same neurons as TRPV1, another thermoTRP, which senses heat.

TRPA1 is sensitive to numerous chemical irritants including cinnamaldehyde, allicin and eugenol. The receptor has been linked to nociceptive transduction and neurogenic inflammation.

External sources of pharmacological information for TRPA1 :

TRPA1 Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TRPA1 Human TRPA1 NM_007332 Y10601
Mouse Trpa1 NM_177781 Q8BLA8
Rat Trpa1 NM_207608 Q6RI86