TRPA1
The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer.
TRPA1 Activators |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 5178 | ASP 7663 |
| Selective TRPA1 activator | |
| 1531 | Icilin |
| Activates a novel cold receptor. Cooling agent | |
| 6269 | JT010 |
| Potent and selective TRPA1 channel activator | |
| 4901 | Optovin |
| Reversible photoactive TRPA1 activator | |
| 3197 | Polygodial |
| TRPA1 channel activator; analgesic and antifungal | |
| 1418 | Resveratrol |
| TRPA1 activator: also cyclooxygenase inhibitor | |
TRPA1 Blockers |
|
| Cat. No. | Product Name / Activity |
| 4716 | A 967079 |
| Selective TRPA1 channel blocker | |
| 5914 | AM 0902 |
| Potent and selective TRPA1 antagonist | |
| 3296 | AP 18 |
| Reversible TRPA1 channel blocker | |
| 2896 | HC 030031 |
| Selective TRPA1 blocker | |
| 3938 | TCS 5861528 |
| TRPA1 blocker | |
The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer. This channel is thought to be indirectly activated by cold; it is often expressed in the same neurons as TRPV1, another thermoTRP, which senses heat.
TRPA1 is sensitive to numerous chemical irritants including cinnamaldehyde, allicin and eugenol. The receptor has been linked to nociceptive transduction and neurogenic inflammation.
External sources of pharmacological information for TRPA1 :
Literature for TRPA1
Tocris offers the following scientific literature for TRPA1 to showcase our products. We invite you to request* your copy today!
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Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
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- Intracellular Signaling
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
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Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization.
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