AMTB hydrochloride

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Description: TRPM8 blocker
Chemical Name: N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Reviews

Biological Activity for AMTB hydrochloride

AMTB hydrochloride is a TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23).

Technical Data for AMTB hydrochloride

M. Wt 430.99
Formula C23H26N2O2S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 926023-82-7
PubChem ID 16095383
InChI Key UDXGBANGPYONOK-UHFFFAOYSA-N
Smiles O=C(N(CC2=CC=CS2)CCCN)C1=C(OCC3=CC(C)=CC=C3)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AMTB hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 43.1 100
DMSO 43.1 100

Preparing Stock Solutions for AMTB hydrochloride

The following data is based on the product molecular weight 430.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.6 mL 23.2 mL
5 mM 0.46 mL 2.32 mL 4.64 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets for AMTB hydrochloride

Certificate of Analysis / Product Datasheet
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References for AMTB hydrochloride

References are publications that support the biological activity of the product.

Lashinger et al (2008) AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am.J.Physiol.Renal Physiol. 295 F803 PMID: 18562636


If you know of a relevant reference for AMTB hydrochloride, please let us know.

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Keywords: AMTB hydrochloride, AMTB hydrochloride supplier, TRPM8, transient, receptor, potential, channels, blockers, TRPM, 3989, Tocris Bioscience

7 Citations for AMTB hydrochloride

Citations are publications that use Tocris products. Selected citations for AMTB hydrochloride include:

Melikov et al (2015) Efficient entry of cell-penetrating peptide nona-arginine into adherent cells involves a transient increase in intracellular calcium. Autophagy 471 221 PMID: 26272944

Diver et al (2019) Structural insights into TRPM8 inhibition and desensitization. Science 365 1434 PMID: 31488702

Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35 PMID: 26330615

Mueller-Tribbensee et al (2015) Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS One 10 e0128242 PMID: 26207981


Do you know of a great paper that uses AMTB hydrochloride from Tocris? Please let us know.

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