TC-I 2014

Pricing Availability   Qty
Description: Potent TRPM8 antagonist
Chemical Name: 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for TC-I 2014

TC-I 2014 is a potent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.

Compound Libraries for TC-I 2014

TC-I 2014 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-I 2014

M. Wt 467.41
Formula C23H19F6N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1221349-53-6
PubChem ID 45274257
Smiles FC(C(C=CC=C3)=C3C1=CC(C(F)(F)F)=C(NC(C4=NOC5(CCCCC5)C4)=N2)C2=C1)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-I 2014

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.74 100
ethanol 46.74 100

Preparing Stock Solutions for TC-I 2014

The following data is based on the product molecular weight 467.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.7 mL 21.39 mL
5 mM 0.43 mL 2.14 mL 4.28 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References for TC-I 2014

References are publications that support the biological activity of the product.

Parks et al (2011) Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J.Med.Chem. 54 233 PMID: 21128593

If you know of a relevant reference for TC-I 2014, please let us know.

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Keywords: TC-I 2014, TC-I 2014 supplier, TC-I2014, TRPM8, antagonist, TRPM, 5410, Tocris Bioscience

1 Citation for TC-I 2014

Citations are publications that use Tocris products. Selected citations for TC-I 2014 include:

Diver et al (2019) Structural insights into TRPM8 inhibition and desensitization. Science 365 1434 PMID: 31488702

Do you know of a great paper that uses TC-I 2014 from Tocris? Please let us know.

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