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Biological Activity for TC-I 2014
TC-I 2014 is a potent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.
Compound Libraries for TC-I 2014
Technical Data for TC-I 2014
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-I 2014
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TC-I 2014
The following data is based on the product molecular weight 467.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.14 mL||10.7 mL||21.39 mL|
|5 mM||0.43 mL||2.14 mL||4.28 mL|
|10 mM||0.21 mL||1.07 mL||2.14 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References for TC-I 2014
References are publications that support the biological activity of the product.
Parks et al (2011) Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J.Med.Chem. 54 233 PMID: 21128593
If you know of a relevant reference for TC-I 2014, please let us know.
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Keywords: TC-I 2014, TC-I 2014 supplier, TC-I2014, TRPM8, antagonist, TRPM, 5410, Tocris Bioscience
1 Citation for TC-I 2014
Citations are publications that use Tocris products. Selected citations for TC-I 2014 include:
Diver et al (2019) Structural insights into TRPM8 inhibition and desensitization. Science 365 1434 PMID: 31488702
Do you know of a great paper that uses TC-I 2014 from Tocris? Please let us know.
Reviews for TC-I 2014
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.