TC-I 2014

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Cat.No. 5410 - TC-I 2014 | C23H19F6N3O | CAS No. 1221349-53-6
Description: Potent TRPM8 antagonist
Chemical Name: 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.

Compound Libraries

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Technical Data

M. Wt 467.41
Formula C23H19F6N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1221349-53-6
PubChem ID 45274257
InChI Key GZINXHRSQAMEQY-ZZEZOPTASA-N
Smiles FC(C(C=CC=C3)=C3C1=CC(C(F)(F)F)=C(NC(C4=NOC5(CCCCC5)C4)=N2)C2=C1)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.74 100
ethanol 46.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 467.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.7 mL 21.39 mL
5 mM 0.43 mL 2.14 mL 4.28 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Parks et al (2011) Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J.Med.Chem. 54 233 PMID: 21128593


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Keywords: TC-I 2014, supplier, TC-I2014, TRPM8, antagonist, TRPM, TRPM, Tocris Bioscience

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Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
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  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.