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Cat.No. 6724 - CBA | C15H11Cl2NO4 | CAS No. 351424-20-9
Description: Selective TRPM4 blocker
Chemical Name: 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity

Selective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.

Compound Libraries

CBA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 340.16
Formula C15H11Cl2NO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 351424-20-9
PubChem ID 2264067
Smiles OC(C1=C(C=C(C=C1)Cl)NC(COC2=C(C=CC=C2)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.01 50

Preparing Stock Solutions

The following data is based on the product molecular weight 340.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.88 mL 29.4 mL 58.8 mL
2.5 mM 1.18 mL 5.88 mL 11.76 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
25 mM 0.12 mL 0.59 mL 1.18 mL

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References are publications that support the biological activity of the product.

Bianchi et al (2018) The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol.Brain. 11 41 PMID: 29996905

Ozhathil et al (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br.J.Pharmacol. 175 2504 PMID: 29579323

If you know of a relevant reference for CBA, please let us know.

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Keywords: CBA, CBA supplier, TRPM4, transient, receptor, potential, melastatin, related, inhibitor, inhibits, blockers, blocks, selective, neuroprotectant, TRPM, 6724, Tocris Bioscience

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Pain Research Product Guide

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.