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Description: Selective TRPM4 blocker
Chemical Name: 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity for CBA

CBA is a selective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.

Compound Libraries for CBA

CBA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CBA

M. Wt 340.16
Formula C15H11Cl2NO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 351424-20-9
PubChem ID 2264067
Smiles OC(C1=C(C=C(C=C1)Cl)NC(COC2=C(C=CC=C2)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CBA

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.01 50

Preparing Stock Solutions for CBA

The following data is based on the product molecular weight 340.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.88 mL 29.4 mL 58.8 mL
2.5 mM 1.18 mL 5.88 mL 11.76 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
25 mM 0.12 mL 0.59 mL 1.18 mL

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References for CBA

References are publications that support the biological activity of the product.

Bianchi et al (2018) The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol.Brain. 11 41 PMID: 29996905

Ozhathil et al (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br.J.Pharmacol. 175 2504 PMID: 29579323

If you know of a relevant reference for CBA, please let us know.

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Keywords: CBA, CBA supplier, TRPM4, transient, receptor, potential, melastatin, related, inhibitor, inhibits, blockers, blocks, selective, neuroprotectant, TRPM, 6724, Tocris Bioscience

3 Citations for CBA

Citations are publications that use Tocris products. Selected citations for CBA include:

O'Malley et al (2020) TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations J Neurosci 40 4813 PMID: 32414784

Douglas A et al (2021) TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing. Cell Rep 34 108714 PMID: 33535052

Tamas et al (2021) Electrophysiological Effects of the Transient Receptor Potential Melastatin 4 Channel Inhibitor (4-Chloro-2-(2-chlorophenoxy)acetamido) Benzoic Acid (CBA) in Canine Left Ventricular Cardiomyocytes. Int J Mol Sci 22 PMID: 34502410

Do you know of a great paper that uses CBA from Tocris? Please let us know.

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