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Potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 289.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||4.61 mL||23.04 mL||46.07 mL|
|3.75 mM||0.92 mL||4.61 mL||9.21 mL|
|7.5 mM||0.46 mL||2.3 mL||4.61 mL|
|37.5 mM||0.09 mL||0.46 mL||0.92 mL|
References are publications that support the biological activity of the product.
Beck et al (2007) Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 41 285 PMID: 16949669
Bodding et al (2007) Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 42 618 PMID: 17517434
If you know of a relevant reference for WS 12, please let us know.
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Keywords: WS 12, WS 12 supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS12, TRPM, 3040, Tocris Bioscience
2 Citations for WS 12
Citations are publications that use Tocris products. Selected citations for WS 12 include:
Liu et al (2013) TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain 154 2169 PMID: 23820004
Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35 PMID: 26330615
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Reviews for WS 12
Average Rating: 5 (Based on 2 Reviews.)
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WS12 was used to activate TRPM8 currents in dorsal root ganglia neurons through whole cell mode patch clamp.
TRP Ion channel, TRPM8 agonist in in vivo experiments in mouse and in vitro tissue, especially Mouse Mesenteric artery to check change in arterial diameter.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.