Potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 289.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.46 mL||17.28 mL||34.55 mL|
|5 mM||0.69 mL||3.46 mL||6.91 mL|
|10 mM||0.35 mL||1.73 mL||3.46 mL|
|50 mM||0.07 mL||0.35 mL||0.69 mL|
References are publications that support the products' biological activity.
Beck et al (2007) Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 41 285 PMID: 16949669
Bodding et al (2007) Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 42 618 PMID: 17517434
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Keywords: WS 12, supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS12, TRPM, TRPM, Tocris Bioscience
1 Citation for WS 12
Citations are publications that use Tocris products. Selected citations for WS 12 include:
Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35 PMID: 26330615
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.