WS 12

Pricing Availability Delivery Time Qty
Cat.No. 3040 - WS 12 | C18H27NO2 | CAS No. 68489-09-8
Description: TRPM8 agonist; cooling agent
Chemical Name: (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).

Technical Data

M. Wt 289.41
Formula C18H27NO2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 68489-09-8
PubChem ID 11266244
InChI Key HNSGVPAAXJJOPQ-XOKHGSTOSA-N
Smiles C[C@H](C)[C@H]1[C@H]([C@@](NC2=CC=C(OC)C=C2)=O)C[C@H](C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 21.71 75

Preparing Stock Solutions

The following data is based on the product molecular weight 289.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.46 mL 17.28 mL 34.55 mL
5 mM 0.69 mL 3.46 mL 6.91 mL
10 mM 0.35 mL 1.73 mL 3.46 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Beck et al (2007) Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 41 285 PMID: 16949669

Bodding et al (2007) Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 42 618 PMID: 17517434


If you know of a relevant reference for WS 12, please let us know.

View Related Products by Target

View Related Products by Product Action

View all TRPM Agonists

Keywords: WS 12, supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS12, TRPM, Tocris Bioscience

1 Citation for WS 12

Citations are publications that use Tocris products. Selected citations for WS 12 include:

Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35 PMID: 26330615


Do you know of a great paper that uses WS 12 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for WS 12

Protocols

TODO: Add Protocols