Retinoid X Receptors

Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; α, β and γ.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
5819 Bexarotene
Potent and selective RXR agonist
3302 CD 3254
Potent and selective RXRα agonist.
3687 Docosahexaenoic acid
RXR agonist
4064 Fluorobexarotene
RXR agonist
5513 Isotretinoin
Endogenous agonist for retinoic acid receptors, Inducer of neuronal differentiation
0695 Retinoic acid
Endogenous retinoic acid receptor agonist
3411 SR 11237
Pan RXR agonist

Antagonists

Cat No Product Name / Activity
3912 HX 531
Potent RXR antagonist
5086 PA 452
RXR antagonist
3303 UVI 3003
RXR antagonist

Modulators

Cat No Product Name / Activity
3508 LG 101506
Selective RXR modulator

Other

Cat No Product Name / Activity
1396 Fenretinide
Synthetic retinoid; antiproliferative and antioxidant
3913 HX 630
RXR synergist
3831 LG 100754
RXR:PPAR agonist
2705 Liarozole dihydrochloride
Blocks retinoic acid metabolism

Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding efficiency of its partner.

Despite numerous studies, the physiological role of RXRs have yet to been fully elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR signaling pathway exists.

There are three RXR subtypes; RXRα, RXRβ and RXRγ, each with two major isoforms (1 and 2). RXRα is expressed in the liver, kidney, epidermis and intestine, RXRβ is widely distributed and RXRγ is restricted to muscle, pituitary gland and certain parts of the brain.

External sources of pharmacological information for Retinoid X Receptors :

    Literature for Retinoid X Receptors

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    Nuclear Receptors

    Nuclear Receptors Product Listing

    A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

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    Retinoid Receptors

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    Retinoid X Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    RXRα Human RXRA NM_002957 P19793
    Mouse Rxra NM_011305 P28700
    Rat Rxra NM_012805 Q05343
    RXRβ Human RXRB NM_021976 P28702
    Mouse Rxrb NM_011306 P28704
    Rat Rxrb NM_206849 P49743
    RXRγ Human RXRG NM_006917 P48443
    Mouse Rxrg NM_011244 P18911
    Rat Rxrg NM_031765 O70464