Retinoid X Receptors
Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; α, β and γ.
Retinoid X Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 5819 | Bexarotene |
| Potent and selective RXR agonist | |
| 3302 | CD 3254 |
| Potent and selective RXRα agonist | |
| 6873 | DC 271 |
| Fluorescent retinoic acid analog; solvochromatic probe | |
| 3687 | Docosahexaenoic acid |
| RXR agonist | |
| 5920 | LG 100268 |
| Potent and selective RXR agonist; also activates RXR/PPARγ heterodimers | |
| 0695 | Retinoic acid |
| Endogenous retinoic acid receptor agonist | |
| 3411 | SR 11237 |
| Pan RXR agonist | |
Retinoid X Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 3912 | HX 531 |
| Potent RXR antagonist | |
| 5086 | PA 452 |
| RXR antagonist | |
| 3303 | UVI 3003 |
| RXR antagonist | |
Retinoid X Receptor Modulators |
|
| Cat. No. | Product Name / Activity |
| 3508 | LG 101506 |
| Selective RXR modulator | |
Other |
|
| Cat. No. | Product Name / Activity |
| 1396 | Fenretinide |
| Synthetic retinoid; antiproliferative and antioxidant | |
| 3913 | HX 630 |
| RXR synergist | |
| 2705 | Liarozole dihydrochloride |
| Blocks retinoic acid metabolism | |
Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding efficiency of its partner.
Despite numerous studies, the physiological role of RXRs have yet to been fully elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR signaling pathway exists.
There are three RXR subtypes; RXRα, RXRβ and RXRγ, each with two major isoforms (1 and 2). RXRα is expressed in the liver, kidney, epidermis and intestine, RXRβ is widely distributed and RXRγ is restricted to muscle, pituitary gland and certain parts of the brain.
External sources of pharmacological information for Retinoid X Receptors :
Literature for Retinoid X Receptors
Tocris offers the following scientific literature for Retinoid X Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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A collection of over 750 products for cancer research, the guide includes research tools for the study of:
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Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.
Retinoid X Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| RXRα | Human | RXRA | NM_002957 | P19793 |
| Mouse | Rxra | NM_011305 | P28700 | |
| Rat | Rxra | NM_012805 | Q05343 | |
| RXRβ | Human | RXRB | NM_021976 | P28702 |
| Mouse | Rxrb | NM_011306 | P28704 | |
| Rat | Rxrb | NM_206849 | P49743 | |
| RXRγ | Human | RXRG | NM_006917 | P48443 |
| Mouse | Rxrg | NM_011244 | P18911 | |
| Rat | Rxrg | NM_031765 | O70464 |
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Our Retinoid Receptors review gives a summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling.
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