Pregnane X Receptors

Pregnane X receptors (PXRs) are nuclear receptors that regulate the expression of CYP3A genes, generating key enzymes involved in xenobiotic metabolism. PXRs also help regulate the induction of P-gp. PXRs are highly expressed in the liver, small intestine and colon.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
4245 Meclizine dihydrochloride
Human pregnane X receptor agonist; H1 antagonist
4121 Rifampicin
Pregnane X receptor agonist; antibiotic
5359 Rifaximin
Pregnane X receptor agonist; antibiotic
2969 SR 12813
Pregnane X receptor agonist

Related Targets

    Pregnane X receptors (PXRs) are nuclear receptors that regulate the expression of CYP3A genes, thus generating key enzymes involved in xenobiotic metabolism. PXRs also help regulate the induction of P-gp. PXRs are highly expressed in the liver, small intestine and colon.

    Numerous ligands activate PXRs, including a range of xenobiotics such as dexamethasone and nifedipine, and naturally occurring steroids. PXR forms a non-permissive heterodimer with RXR receptors in order to bind the promoter and enhancer of the CYP3A4 gene.

    Literature for Pregnane X Receptors

    Nuclear Receptors

    Nuclear Receptors Product Listing

    A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

    • Androgen Receptors
    • Estrogen Receptors
    • Retinoic Acid Receptors
    • Retinoid X Receptors
    • Vitamin D Receptors
    Retinoid Receptors

    Retinoid Receptors Scientific Review

    Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.

    Pregnane X Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    NR1I2 Human NR1I2 NM_003889 O75469
    Rat Nr1i2 NM_052980 Q3B7V1