LG 100268

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Cat.No. 5920 - LG 100268 | C24H29NO2 | CAS No. 153559-76-3
Description: Potent and selective RXR agonist; also activates RXR/PPARγ heterodimers
Chemical Name: 6-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective retinoid X receptor (RXR) agonist (EC50 = 4 nM). Displays >1000-fold selectivity for RXR over RAR. Activates RXR homodimers to induce transcriptional activation. Induces tissue transglutaminase (TGase) activity in HL-60 human promyelocytic leukemia cell line. Also activates RXR/PPARγ heterodimers.

Technical Data

M. Wt 363.49
Formula C24H29NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 153559-76-3
PubChem ID 3922
InChI Key SLXTWXQUEZSSTJ-UHFFFAOYSA-N
Smiles CC1=C(C2(C3=CC=C(C(O)=O)C=N3)CC2)C=C4C(C(C)(CCC4(C)C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 363.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.51 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lala et al (1996) Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 383 450 PMID: 8837780

Boehm et al (1995) Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J.Med.Chem. 38 3146 PMID: 7636877


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Keywords: LG 100268, supplier, LG100268, Retiniod, X, receptor, RXR, agonists, activators, activates, potent, selective, Retinoid, X, Receptor, PPARgamma, Receptors, Retinoid, X, Receptor, Tocris Bioscience

Citations for LG 100268

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