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Biological Activity for LG 100268
LG 100268 is a potent and selective retinoid X receptor (RXR) agonist (EC50 = 4 nM). Displays >1000-fold selectivity for RXR over RAR. Activates RXR homodimers to induce transcriptional activation. Induces tissue transglutaminase (TGase) activity in HL-60 human promyelocytic leukemia cell line. Also activates RXR/PPARγ heterodimers.
Compound Libraries for LG 100268
Technical Data for LG 100268
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LG 100268
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for LG 100268
The following data is based on the product molecular weight 363.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.5 mL||27.51 mL||55.02 mL|
|2.5 mM||1.1 mL||5.5 mL||11 mL|
|5 mM||0.55 mL||2.75 mL||5.5 mL|
|25 mM||0.11 mL||0.55 mL||1.1 mL|
References for LG 100268
References are publications that support the biological activity of the product.
Lala et al (1996) Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 383 450 PMID: 8837780
Boehm et al (1995) Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J.Med.Chem. 38 3146 PMID: 7636877
If you know of a relevant reference for LG 100268, please let us know.
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Keywords: LG 100268, LG 100268 supplier, LG100268, Retiniod, X, receptor, RXR, agonists, activators, activates, potent, selective, Retinoid, Receptor, PPARgamma, Receptors, 5920, Tocris Bioscience
Citations for LG 100268
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Literature in this Area
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