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Potent and selective retinoid X receptor (RXR) agonist (EC50 = 4 nM). Displays >1000-fold selectivity for RXR over RAR. Activates RXR homodimers to induce transcriptional activation. Induces tissue transglutaminase (TGase) activity in HL-60 human promyelocytic leukemia cell line. Also activates RXR/PPARγ heterodimers.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 363.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.5 mL||27.51 mL||55.02 mL|
|2.5 mM||1.1 mL||5.5 mL||11 mL|
|5 mM||0.55 mL||2.75 mL||5.5 mL|
|25 mM||0.11 mL||0.55 mL||1.1 mL|
References are publications that support the biological activity of the product.
Lala et al (1996) Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 383 450 PMID: 8837780
Boehm et al (1995) Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J.Med.Chem. 38 3146 PMID: 7636877
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Keywords: LG 100268, LG 100268 supplier, LG100268, Retiniod, X, receptor, RXR, agonists, activators, activates, potent, selective, Retinoid, Receptor, PPARgamma, Receptors, 5920, Tocris Bioscience
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