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Endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 328.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.04 mL||15.22 mL||30.44 mL|
|5 mM||0.61 mL||3.04 mL||6.09 mL|
|10 mM||0.3 mL||1.52 mL||3.04 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
References are publications that support the biological activity of the product.
Mata de Urqunia et al (2000) Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290 2140 PMID: 11118147
Zapata-Gonzalez et al (2008) Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids. J.Leukoc.Biol. 84 1172 PMID: 18632990
Hossain et al (2009) Mechanism of docosahexaenoic acid-induced inhibition of in vitro Aβ1-42 fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells. J.Neurochem. 111 568 PMID: 19686246
If you know of a relevant reference for Docosahexaenoic acid, please let us know.
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Keywords: Docosahexaenoic acid, Docosahexaenoic acid supplier, RXR, agonists, retinoid, X, receptors, selective, DHA, Retinoid, Receptor, 3687, Tocris Bioscience
2 Citations for Docosahexaenoic acid
Citations are publications that use Tocris products. Selected citations for Docosahexaenoic acid include:
Wnuk et al (2018) Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Mol Neurobiol 55 5059 PMID: 28815487
Reyes-Reveles et al (2017) Phagocytosis-dependent ketogenesis in retinal pigment epithelium. J Biol Chem 292 8038 PMID: 28302729
Do you know of a great paper that uses Docosahexaenoic acid from Tocris? Please let us know.
Reviews for Docosahexaenoic acid
Average Rating: 3 (Based on 1 Review.)
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DHA used to verify if cells can metabolise various lipids. No effect seen here with DHA but we would need more controls to evaluate the product itself.
Literature in this Area
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