Docosahexaenoic acid

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Cat.No. 3687 - Docosahexaenoic acid | C22H32O2 | CAS No. 6217-54-5
Description: RXR agonist
Alternative Names: DHA
Chemical Name: (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.

Technical Data

M. Wt 328.49
Formula C22H32O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 6217-54-5
PubChem ID 445580
InChI Key MBMBGCFOFBJSGT-KUBAVDMBSA-N
Smiles CC\C=C/C\C=C/C\C=C/C/C=C\C/C=C\C/C=C\CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.85 100
ethanol 32.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 328.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.22 mL 30.44 mL
5 mM 0.61 mL 3.04 mL 6.09 mL
10 mM 0.3 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Mata de Urqunia et al (2000) Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290 2140 PMID: 11118147

Zapata-Gonzalez et al (2008) Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids. J.Leukoc.Biol. 84 1172 PMID: 18632990

Hossain et al (2009) Mechanism of docosahexaenoic acid-induced inhibition of in vitro1-42 fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells. J.Neurochem. 111 568 PMID: 19686246


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Keywords: Docosahexaenoic acid, Docosahexaenoic acid supplier, RXR, agonists, retinoid, X, receptors, selective, DHA, Retinoid, Receptor, 3687, Tocris Bioscience

Citations for Docosahexaenoic acid

Citations are publications that use Tocris products.

Currently there are no citations for Docosahexaenoic acid. Do you know of a great paper that uses Docosahexaenoic acid from Tocris? Please let us know.

Reviews for Docosahexaenoic acid

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DHA
By Anonymous on 01/31/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Brain Slice

DHA used to verify if cells can metabolise various lipids. No effect seen here with DHA but we would need more controls to evaluate the product itself.


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