Vitamin D Receptors

Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X receptors (PXR) and constitutive androstane receptors (CAR). They form heterodimers with retinoid X receptor family members, and are expressed in the intestine, thyroid and kidney.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2551 Calcitriol
Vitamin D receptor (VDR) agonist
3206 Doxercalciferol
Vitamin D2 analog, VDR agonist
3993 EB 1089
Vitamin D receptor (VDR) agonist
3970 Ercalcitriol
Active metabolite of vitamin D2

Other

Cat No Product Name / Activity
4159 Alfacalcidol
Prodrug of vitamin D3 (Cat. No. 4156)
4036 Calcifediol
Prohormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D
2700 Calcipotriol
Vitamin D3 analog
4146 Ercalcidiol
Metabolite of vitamin D2
4160 22-Oxacalcitriol
Non-calcemic vitamin D3 (Cat. No. 4156) analog
4161 Paricalcitol
Analog of the active form of vitamin D2
4157 Tacalcitol
Synthetic vitamin D3 (Cat. No. 4156) analog
4156 Vitamin D3
Precursor of calcifediol (Cat. No. 4036). Naturally occurring form of vitamin D

Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X receptors (PXR) and constitutive androstane receptors (CAR). They form heterodimers with members of the retinoid X receptor family. VDR is expressed in the intestine, thyroid and kidney.

VDRs repress expression of 1α-hydroxylase (the proximal activator of 1,25(OH)2D3) and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Also, it has recently been identified as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. Inherited mutations in the VDR gene leads to rickets, which is characterized by muscle weakness, growth retardation, bone deformity and secondary hyperparathyroidism. The human gene encoding the vitamin D receptor has been localized to chromosome 12q12-q14.

External sources of pharmacological information for Vitamin D Receptors :

    Literature for Vitamin D Receptors

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
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    Nuclear Receptors

    Nuclear Receptors Product Listing

    A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

    • Androgen Receptors
    • Estrogen Receptors
    • Retinoic Acid Receptors
    • Retinoid X Receptors
    • Vitamin D Receptors

    VDR-like Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    VDR Human VDR NM_001017535 P11473
    Mouse Vdr NM_009504 P48281
    Rat Vdr NM_009504 P48281
    PXR Human NR1I2 NM_033013 Q9UJ26
    Mouse Nr1i2 NM_010936 O54915
    Rat Nr1i2 NM_052980 Q3B7V1
    CAR Human NR1I3 NM_001077475 Q14994
    Mouse Nr1i3 NM_009803 O35627
    Rat Nr1i3 NM_022941 Q402B9