Retinoid Receptors Scientific Review

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Retinoid Receptors Scientific Review

Pharmacology of Retinoid Receptors

Alexander R. Moise, University of Kansas

Review excerpt: "Retinoid signaling can induce cellular differentiation or apoptosis, which is partly relevant in the treatment of cancer. Due to this, there has been a tremendous effort to develop safe and receptor-selective compounds. Structural analysis of various receptors in combination with ATRA, 9-cis-RA or synthetic agonists or antagonists has provided the retinoid field with an unprecedented molecular understanding of the subtle changes necessary to produce the desired receptor response and to confer specific activity."