Fenretinide

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Cat.No. 1396 - Fenretinide | C26H33NO2 | CAS No. 65646-68-6
Description: Synthetic retinoid; antiproliferative and antioxidant
Alternative Names: 4-HPR
Chemical Name: N-(4-Hydroxyphenyl)retinamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

Deuterated analog also available.

Technical Data

M. Wt 391.55
Formula C26H33NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 65646-68-6
PubChem ID 5288209
InChI Key AKJHMTWEGVYYSE-FXILSDISSA-N
Smiles CC(/C=C/C1=C(C)CCCC1(C)C)=C\C=C\C(C)=C\C(=O)NC1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.16 100
ethanol 39.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 391.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Le Doze et al (2000) Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of rat. Drug Metab.Dispos. 28 205 PMID: 10640519

Takahashi (2000) Antioxidant properties of N-(4-hydroxyphenyl)retinamide (fenretinide). Biol.Pharm.Bull. 23 222 PMID: 10706389

Ulukaya and Wood (1999) Fenretinide and its relation to cancer. Cancer Treat.Rev. 25 229 PMID: 10448131


If you know of a relevant reference for Fenretinide, please let us know.

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Keywords: Fenretinide, supplier, Synthetic, retinoid, agonists, Potent, anti-cancer, agent, RXR, Retinoid, X, Receptors, RAR, RAMBA, Retinoic, Acid, 4-HPR, Retinoic, Acid, Receptors, Retinoid, X, Receptor, Retinoic, Acid, Receptors, Tocris Bioscience

2 Citations for Fenretinide

Citations are publications that use Tocris products. Selected citations for Fenretinide include:

Seidensaal et al (2015) Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma. Am J Pathol 14 204 PMID: 26634247

Johansson et al (2013) Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Commun 4 2175 PMID: 23868472


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