Fenretinide

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Cat.No. 1396 - Fenretinide | C26H33NO2 | CAS No. 65646-68-6
Description: Synthetic retinoid; antiproliferative and antioxidant
Alternative Names: 4-HPR
Chemical Name: N-(4-Hydroxyphenyl)retinamide
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews (1)
Literature (3)

Biological Activity

Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

Technical Data

M. Wt 391.55
Formula C26H33NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 65646-68-6
PubChem ID 5288209
InChI Key AKJHMTWEGVYYSE-FXILSDISSA-N
Smiles CC(/C=C/C1=C(C)CCCC1(C)C)=C\C=C\C(C)=C\C(=O)NC1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 39.16 100
DMSO 39.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 391.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Le Doze et al (2000) Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of rat. Drug Metab.Dispos. 28 205 PMID: 10640519

Takahashi (2000) Antioxidant properties of N-(4-hydroxyphenyl)retinamide (fenretinide). Biol.Pharm.Bull. 23 222 PMID: 10706389

Ulukaya and Wood (1999) Fenretinide and its relation to cancer. Cancer Treat.Rev. 25 229 PMID: 10448131


If you know of a relevant reference for Fenretinide, please let us know.

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Keywords: Fenretinide, Fenretinide supplier, Synthetic, retinoid, agonists, Potent, anti-cancer, agent, RXR, Retinoid, X, Receptors, RAR, RAMBA, Retinoic, Acid, 4-HPR, Receptor, 1396, Tocris Bioscience

Reviews for Fenretinide

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Fenretinide was tested to understand its induction of apoptotic cell death in B-cell non-Hodgkin lymphoma.
By Anonymous on 12/23/2019
Species: Human

Fenretinide was tested to understand its induction of apoptotic cell death in B-cell non-Hodgkin lymphoma (NHL).

Fenretinide at 900 mg/m2 PO BID for days 1–5 of a 7-day cycle used.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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