Ro 32-0432 hydrochloride

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Cat.No. 1587 - Ro 32-0432 hydrochloride | C28H28N4O2.HCl | CAS No. 151342-35-7
Description: Potent, orally active PKC inhibitor
Chemical Name: 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.

Technical Data

M. Wt 489.01
Formula C28H28N4O2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 151342-35-7
PubChem ID 70346044
InChI Key HSPRASOZRZDELU-LMOVPXPDSA-N
Smiles O=C(N1)C(C2=C6N(CC[C@H](CN(C)C)C6)C3=CC=CC=C23)=C(C(C5=C4C=CC=C5)=CN4C)C1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.89 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 489.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.22 mL 20.45 mL
5 mM 0.41 mL 2.04 mL 4.09 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wilkinson et al (1993) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem.J. 294 335 PMID: 8373348

Birchall et al (1994) Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J.Pharmacol.Exp.Ther. 268 922 PMID: 8114006


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Keywords: Ro 32-0432 hydrochloride, supplier, Potent, orally, active, PKC, inhibitors, inhibits, Protein, Kinases, C, Ro32-0432, hydrochloride, Protein, Kinase, C, Protein, Kinase, C, Tocris Bioscience

2 Citations for Ro 32-0432 hydrochloride

Citations are publications that use Tocris products. Selected citations for Ro 32-0432 hydrochloride include:

Robert et al (2009) Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS One 4 e7889 PMID: 19924252

Signore et al (2014) Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo. Cell Death Dis 5 e1223 PMID: 24810059


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