Ro 32-0432 hydrochloride

Pricing Availability   Qty
Description: Potent, orally active PKC inhibitor
Chemical Name: 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for Ro 32-0432 hydrochloride

Ro 32-0432 hydrochloride is a selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.

Technical Data for Ro 32-0432 hydrochloride

M. Wt 489.01
Formula C28H28N4O2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1781828-85-0
PubChem ID 70346044
Smiles O=C(N1)C(C2=C6N(CC[C@H](CN(C)C)C6)C3=CC=CC=C23)=C(C(C5=C4C=CC=C5)=CN4C)C1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 32-0432 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.89 10 with gentle warming

Preparing Stock Solutions for Ro 32-0432 hydrochloride

The following data is based on the product molecular weight 489.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.45 mL 102.25 mL 204.49 mL
0.5 mM 4.09 mL 20.45 mL 40.9 mL
1 mM 2.04 mL 10.22 mL 20.45 mL
5 mM 0.41 mL 2.04 mL 4.09 mL

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Product Datasheets for Ro 32-0432 hydrochloride

References for Ro 32-0432 hydrochloride

References are publications that support the biological activity of the product.

Wilkinson et al (1993) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem.J. 294 335 PMID: 8373348

Birchall et al (1994) Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J.Pharmacol.Exp.Ther. 268 922 PMID: 8114006

If you know of a relevant reference for Ro 32-0432 hydrochloride, please let us know.

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2 Citations for Ro 32-0432 hydrochloride

Citations are publications that use Tocris products. Selected citations for Ro 32-0432 hydrochloride include:

Robert et al (2009) Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS One 4 e7889 PMID: 19924252

Signore et al (2014) Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo. Cell Death Dis 5 e1223 PMID: 24810059

Do you know of a great paper that uses Ro 32-0432 hydrochloride from Tocris? Please let us know.

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