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Ro 32-0432 hydrochloride is a selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.89||10 with gentle warming|
The following data is based on the product molecular weight 489.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||20.45 mL||102.25 mL||204.49 mL|
|0.5 mM||4.09 mL||20.45 mL||40.9 mL|
|1 mM||2.04 mL||10.22 mL||20.45 mL|
|5 mM||0.41 mL||2.04 mL||4.09 mL|
References are publications that support the biological activity of the product.
Wilkinson et al (1993) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem.J. 294 335 PMID: 8373348
Birchall et al (1994) Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J.Pharmacol.Exp.Ther. 268 922 PMID: 8114006
If you know of a relevant reference for Ro 32-0432 hydrochloride, please let us know.
Keywords: Ro 32-0432 hydrochloride, Ro 32-0432 hydrochloride supplier, Potent, orally, active, PKC, inhibitors, inhibits, Protein, Kinases, C, Ro32-0432, hydrochloride, Kinase, 1587, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Ro 32-0432 hydrochloride include:
Robert et al (2009) Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS One 4 e7889 PMID: 19924252
Signore et al (2014) Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo. Cell Death Dis 5 e1223 PMID: 24810059
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