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Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
(Modifications: Ser-1 = Myr-Ser)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID: 15728837
Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141 PMID: 16931766
Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295
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Keywords: ZIP, ZIP supplier, Cell-permeable, inhibitors, inhibits, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C, z-Pseudosubstrate, inhibitory, peptide, Kinase, 2549, Tocris Bioscience
8 Citations for ZIP
Citations are publications that use Tocris products. Selected citations for ZIP include:
Grosso et al (2015) The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli. Nat Commun 6 8886 PMID: 26619940
Lee et al (2013) Prkcz null mice show normal learning and memory. Nature 493 416 PMID: 23283171
Awasthi et al (2019) Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science 363 PMID: 30545844
Balaban et al Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci 9 222 PMID: 26157359
Mirza et al (2017) Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight 2 PMID: 29093271
Laferrière et al (2011) PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain. Autophagy 7 99 PMID: 22185613
Han et al (2015) Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury. J Neurophysiol 2015 601767 PMID: 26457205
Chen et al (2015) Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity. Mol Pain 113 3047 PMID: 25761958
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