ZIP

Pricing Availability Delivery Time Qty
Cat.No. 2549 - ZIP | Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu | CAS No. 863987-12-6
Description: Cell-permeable inhibitor of atypical PKC isozyme PKMζ
Alternative Names: z-Pseudosubstrate inhibitory peptide
Datasheet
Citations (5)
Literature

Biological Activity

Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.

Technical Data

M. Wt 1982.4
Formula C90H154N30O17
Sequence SIYRRGARRWRKL

(Modifications: Ser-1 = Myr-Ser)

Storage Desiccate at -20°C
CAS Number 863987-12-6
PubChem ID 16156119
InChI Key CRKARHQCXWSUMV-HOHDCHNJSA-N
Smiles [H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1982.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.5 mL 2.52 mL 5.04 mL
5 mM 0.1 mL 0.5 mL 1.01 mL
10 mM 0.05 mL 0.25 mL 0.5 mL
50 mM 0.01 mL 0.05 mL 0.1 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID: 15728837

Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141 PMID: 16931766

Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295 PMID:


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Keywords: Cell-permeable inhibitors inhibits atypical PKC isozyme PKMzeta Protein Kinases C z-Pseudosubstrate inhibitory peptide Protein Kinase C

5 Citations for ZIP

Citations are publications that use Tocris products. Selected citations for ZIP include:

Han et al (2015) Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury. J Neurophysiol 2015 601767 PMID: 26457205

Chen et al (2015) Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity. Mol Pain 113 3047 PMID: 25761958

Lee et al (2013) Prkcz null mice show normal learning and memory. Nature 493 416 PMID: 23283171

Laferrière et al (2011) PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain. Autophagy 7 99 PMID: 22185613

Balaban et al Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci 9 222 PMID: 26157359


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