Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
(Modifications: Ser-1 = Myr-Ser)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1982.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.5 mL||2.52 mL||5.04 mL|
|5 mM||0.1 mL||0.5 mL||1.01 mL|
|10 mM||0.05 mL||0.25 mL||0.5 mL|
|50 mM||0.01 mL||0.05 mL||0.1 mL|
References are publications that support the products' biological activity.
Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID: 15728837
Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141 PMID: 16931766
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Keywords: ZIP, supplier, Cell-permeable, inhibitors, inhibits, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C, z-Pseudosubstrate, inhibitory, peptide, Protein, Kinase, C, Protein, Kinase, C, Tocris Bioscience
5 Citations for ZIP
Citations are publications that use Tocris products. Selected citations for ZIP include:
Laferrière et al (2011) PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain. Autophagy 7 99 PMID: 22185613
Balaban et al Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci 9 222 PMID: 26157359
Han et al (2015) Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury. J Neurophysiol 2015 601767 PMID: 26457205
Chen et al (2015) Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity. Mol Pain 113 3047 PMID: 25761958
Lee et al (2013) Prkcz null mice show normal learning and memory. Nature 493 416 PMID: 23283171
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Literature in this Area
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