ZIP

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Description: Cell-permeable inhibitor of atypical PKC isozyme PKMζ
Alternative Names: z-Pseudosubstrate inhibitory peptide
Purity: ≥95% (HPLC)
Datasheet
Citations (8)
Reviews

Biological Activity for ZIP

ZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Control Peptide and Biotinylated Peptide also available.

Technical Data for ZIP

M. Wt 1928.4
Formula C90H154N30O17
Sequence SIYRRGARRWRKL

(Modifications: Ser-1 = Myr-Ser)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 863987-12-6
PubChem ID 16156119
InChI Key CRKARHQCXWSUMV-HOHDCHNJSA-N
Smiles [H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ZIP

Solubility Soluble to 1 mg/ml in water

Product Datasheets for ZIP

Certificate of Analysis / Product Datasheet
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References for ZIP

References are publications that support the biological activity of the product.

Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID: 15728837

Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141 PMID: 16931766

Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295


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Keywords: ZIP, ZIP supplier, Cell-permeable, inhibitors, inhibits, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C, z-Pseudosubstrate, inhibitory, peptide, Kinase, 2549, Tocris Bioscience

8 Citations for ZIP

Citations are publications that use Tocris products. Selected citations for ZIP include:

Han et al (2015) Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury. J Neurophysiol 2015 601767 PMID: 26457205

Chen et al (2015) Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity. Mol Pain 113 3047 PMID: 25761958

Lee et al (2013) Prkcz null mice show normal learning and memory. Nature 493 416 PMID: 23283171

Mirza et al (2017) Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight 2 PMID: 29093271


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