TAT-SAMβA Peptide

Pricing Availability   Qty
Description: Selective antagonist of Mfn1-βIIPKC association
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for TAT-SAMβA Peptide

TAT-SAMβA Peptide is a selective antagonist of Mfn1-βIIPKC association. Comprises the cell permeable peptide TAT47-57, conjugated to βIIPKC624-632 by a Gly-Gly spacer. TAT-SAMβA Peptide reduces mitochondrial fragmentation and stress-induced death in cultured cardiomyocytes. In rats with heart failure, TAT-SAMβA Peptide restores mitochondrial morphology, bioenergetics, and redox balance, which leads to improvement in cardiac contractility.

Technical Data for TAT-SAMβA Peptide

M. Wt 2824.16
Formula C118H195N51O31
Sequence YGRKKRRQRRRGGRNAENFDRF
Storage Store at -20°C
Purity ≥95% (HPLC)
InChI Key RGMNLQQBUQABCW-OODSNGTQSA-N
Smiles DSO=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC3=CC=C(C=C3)O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAT-SAMβA Peptide

Solubility Soluble to 2 mg/ml in water

Product Datasheets for TAT-SAMβA Peptide

References for TAT-SAMβA Peptide

References are publications that support the biological activity of the product.

Ferreira et al (2019) A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat.Commun. 10 329 PMID: 30659190

Zacharioudakis et al (2022) Mitochondrial dynamics proteins as emerging drug targets. Trends Pharmacol.Sci. 44 112 PMID: 36496299


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Keywords: TAT-SAMbA Peptide, TAT-SAMbA Peptide supplier, SAMbA, SAMbetaA, peptide, antagonist, Mfn1-bIIPKC, mitochondrial, dynamics, mitochondria, TAT, SAMBA, cardiomyocytes, Mfn1, bIIPKC, betaIIPKC, Protein, Kinase, C, 7962, Tocris Bioscience

Citations for TAT-SAMβA Peptide

Citations are publications that use Tocris products.

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