Bryostatin 1

Pricing Availability Delivery Time Qty
Cat.No. 2383 - Bryostatin 1 | C47H68O17 | CAS No. 83314-01-6
Description: Protein kinase C activator
Alternative Names: NSC 339555
Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Technical Data

M. Wt 905.04
Formula C47H68O17
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 83314-01-6
PubChem ID 5280757
InChI Key MJQUEDHRCUIRLF-TVIXENOKSA-N
Smiles O=C(C)O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO and in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 905.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.1 mL 5.52 mL 11.05 mL
5 mM 0.22 mL 1.1 mL 2.21 mL
10 mM 0.11 mL 0.55 mL 1.1 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lorenzo et al (1997) The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1. J.Biol.Chem. 272 33338 PMID: 9407126

Sun and Alkon (2006) Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug Rev. 12 1 PMID: 16834754

Wender et al (1998) The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proc.Natl.Acad.Sci.USA 95 6624 PMID: 9618462

Sun et al (2014) Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice. J Pharmacol Exp Ther. 349 393 PMID: 24659806


If you know of a relevant reference for Bryostatin 1, please let us know.

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Keywords: Protein kinases C activators PKC Bryostatin1 NSC339555 NSC 339555 Protein Kinase C

2 Citations for Bryostatin 1

Citations are publications that use Tocris products. Selected citations for Bryostatin 1 include:

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Lin et al (2016) Neuronal splicing regulator RBFOX3(NeuN) regulates adult hippocampal neurogenesis and synaptogenesis PLoS One 11 e0164164 PMID: 27701470


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Pathways for Bryostatin 1

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