Bryostatin 1

Pricing Availability   Qty
Cat.No. 2383 - Bryostatin 1 | C47H68O17 | CAS No. 83314-01-6
Description: Protein kinase C activator
Alternative Names: NSC 339555
Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Technical Data

M. Wt 905.04
Formula C47H68O17
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 83314-01-6
PubChem ID 5280757
InChI Key MJQUEDHRCUIRLF-TVIXENOKSA-N
Smiles O=C(C)O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in DMSO and in ethanol

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Lorenzo et al (1997) The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1. J.Biol.Chem. 272 33338 PMID: 9407126

Sun and Alkon (2006) Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug Rev. 12 1 PMID: 16834754

Wender et al (1998) The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proc.Natl.Acad.Sci.USA 95 6624 PMID: 9618462

Sun et al (2014) Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice. J Pharmacol Exp Ther. 349 393 PMID: 24659806


If you know of a relevant reference for Bryostatin 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Protein Kinase C Activators

Keywords: Bryostatin 1, Bryostatin 1 supplier, Protein, kinases, C, activators, PKC, Bryostatin1, NSC339555, NSC, 339555, Kinase, 2383, Tocris Bioscience

6 Citations for Bryostatin 1

Citations are publications that use Tocris products. Selected citations for Bryostatin 1 include:

Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401

Schaffer et al (2018) PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep 25 2470 PMID: 30485813

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Lin et al (2016) Neuronal splicing regulator RBFOX3(NeuN) regulates adult hippocampal neurogenesis and synaptogenesis PLoS One 11 e0164164 PMID: 27701470

Marsden (2018) Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. Virology 520 83 PMID: 29800728

Kornberg (2018) Bryostatin-1 alleviates experimental multiple sclerosis. Proc Natl Acad Sci U S A. 115 2186 PMID: 29440425


Do you know of a great paper that uses Bryostatin 1 from Tocris? Please let us know.

Reviews for Bryostatin 1

There are currently no reviews for this product. Be the first to review Bryostatin 1 and earn rewards!

Have you used Bryostatin 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling