Bryostatin 1

Pricing Availability   Qty
Description: Protein kinase C activator
Alternative Names: NSC 339555
Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester
Purity: ≥98% (HPLC)
Citations (6)
Reviews (1)

Biological Activity for Bryostatin 1

Bryostatin 1 is a protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Technical Data for Bryostatin 1

M. Wt 905.04
Formula C47H68O17
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 83314-01-6
PubChem ID 5280757
Smiles O=C(C)O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bryostatin 1

Solubility Soluble in DMSO and in ethanol

Product Datasheets for Bryostatin 1

Certificate of Analysis / Product Datasheet
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References for Bryostatin 1

References are publications that support the biological activity of the product.

Lorenzo et al (1997) The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1. J.Biol.Chem. 272 33338 PMID: 9407126

Sun and Alkon (2006) Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug Rev. 12 1 PMID: 16834754

Wender et al (1998) The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proc.Natl.Acad.Sci.USA 95 6624 PMID: 9618462

Sun et al (2014) Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice. J Pharmacol Exp Ther. 349 393 PMID: 24659806

If you know of a relevant reference for Bryostatin 1, please let us know.

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Keywords: Bryostatin 1, Bryostatin 1 supplier, Protein, kinases, C, activators, PKC, Bryostatin1, NSC339555, NSC, 339555, Kinase, 2383, Tocris Bioscience

6 Citations for Bryostatin 1

Citations are publications that use Tocris products. Selected citations for Bryostatin 1 include:

Kornberg (2018) Bryostatin-1 alleviates experimental multiple sclerosis. Proc Natl Acad Sci U S A. 115 2186 PMID: 29440425

Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401

Schaffer et al (2018) PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep 25 2470 PMID: 30485813

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Do you know of a great paper that uses Bryostatin 1 from Tocris? Please let us know.

Reviews for Bryostatin 1

Average Rating: 4 (Based on 1 Review.)

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Mitochondrial bioenergetics measurements by reagent screen.
By Anonymous on 03/15/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: mouse brain endothelioma cell line

50 nM

PMID: 27978828
review image