Melittin

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Description: Inhibits Gs and stimulates Gi activity
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Melittin

Melittin is a inhibits Gs and stimulates Gi activity. Inhibits protein kinase C and cAMP-dependent protein kinases. Na+/K+ ATPase inhibitor.

Technical Data for Melittin

M. Wt 2847
Formula C131H229N39O31
Sequence GIGAVLKVLTTGLPALISWIKRKRQQ

(Modification: Gln-26 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 20449-79-0
PubChem ID 16133648
InChI Key VDXZNPDIRNWWCW-JFTDCZMZSA-N
Smiles [H]NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Melittin

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Melittin

Certificate of Analysis / Product Datasheet
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References for Melittin

References are publications that support the biological activity of the product.

Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting Gs activity. Peptides 5 811 PMID: 9663445

Mousli et al (1990) G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. TiPS 11 358 PMID: 2122563

Raynor et al (1991) Membrane interactions of amphiphilic polypeptides mastoparan, melittin, plymixin B and cardiotoxin. J.Biol.Chem. 266 2753 PMID: 1847132


If you know of a relevant reference for Melittin, please let us know.

Keywords: Melittin, Melittin supplier, Inhibitors, inhibits, Gs, stimulates, stimulators, Gi, activity, protein, kinases, C, cAMP-dependent, G, Proteins, Heterotrimeric, PKC, G-protein, GTPases, Protein, Kinase, 1193, Tocris Bioscience

1 Citation for Melittin

Citations are publications that use Tocris products. Selected citations for Melittin include:

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600


Do you know of a great paper that uses Melittin from Tocris? Please let us know.

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