You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
CRT 0066854 hydrochloride
Biological Activity for CRT 0066854 hydrochloride
CRT 0066854 hydrochloride is a protein kinase C (PKC) inhibitor. Inhibits PKCι and PKCζ (IC50 values are 132 and 639 nM, respectively). Restores polarized morphogenesis in oncogene expressing MDCK cells, decreases colony formation in HeLa cells and inhibits lethal giant larvae 2 (LLGL2) phosphorylation.
Compound Libraries for CRT 0066854 hydrochloride
Technical Data for CRT 0066854 hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CRT 0066854 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CRT 0066854 hydrochloride
The following data is based on the product molecular weight 488.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.05 mL||10.24 mL||20.47 mL|
|5 mM||0.41 mL||2.05 mL||4.09 mL|
|10 mM||0.2 mL||1.02 mL||2.05 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
Product Datasheets for CRT 0066854 hydrochloride
References for CRT 0066854 hydrochloride
References are publications that support the biological activity of the product.
Linch et al (2014) Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis 35 396 PMID: 24072773
Kjaer et al (2013) Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem.J. 451 329 PMID: 23418854
If you know of a relevant reference for CRT 0066854 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: CRT 0066854 hydrochloride, CRT 0066854 hydrochloride supplier, CRT0066854, HCl, PKCiota, inhibitors, inhibits, protein, kinase, C, iota, PKCzeta, Protein, Kinase, 5922, Tocris Bioscience
Citations for CRT 0066854 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for CRT 0066854 hydrochloride. Do you know of a great paper that uses CRT 0066854 hydrochloride from Tocris? Please let us know.
Reviews for CRT 0066854 hydrochloride
There are currently no reviews for this product. Be the first to review CRT 0066854 hydrochloride and earn rewards!
Have you used CRT 0066854 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.