CRT 0066854 hydrochloride

Pricing Availability   Qty
Cat.No. 5922 - CRT 0066854 hydrochloride | C24H25N5S.2HCl | CAS No. 2250019-91-9
Description: PKCι and PKCζ inhibitor
Chemical Name: (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for CRT 0066854 hydrochloride

CRT 0066854 hydrochloride is a protein kinase C (PKC) inhibitor. Inhibits PKCι and PKCζ (IC50 values are 132 and 639 nM, respectively). Restores polarized morphogenesis in oncogene expressing MDCK cells, decreases colony formation in HeLa cells and inhibits lethal giant larvae 2 (LLGL2) phosphorylation.

Compound Libraries for CRT 0066854 hydrochloride

CRT 0066854 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CRT 0066854 hydrochloride

M. Wt 488.48
Formula C24H25N5S.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250019-91-9
PubChem ID 131954580
Smiles N[C@@H](CC1=CC=CC=C1)CNC2=C3C4=C(SC3=NC(C5=CC=NC=C5)=N2)CCCC4.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CRT 0066854 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 48.85 100
DMSO 48.85 100

Preparing Stock Solutions for CRT 0066854 hydrochloride

The following data is based on the product molecular weight 488.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.24 mL 20.47 mL
5 mM 0.41 mL 2.05 mL 4.09 mL
10 mM 0.2 mL 1.02 mL 2.05 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for CRT 0066854 hydrochloride

References for CRT 0066854 hydrochloride

References are publications that support the biological activity of the product.

Linch et al (2014) Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis 35 396 PMID: 24072773

Kjaer et al (2013) Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem.J. 451 329 PMID: 23418854

If you know of a relevant reference for CRT 0066854 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Protein Kinase C Inhibitors

Keywords: CRT 0066854 hydrochloride, CRT 0066854 hydrochloride supplier, CRT0066854, HCl, PKCiota, inhibitors, inhibits, protein, kinase, C, iota, PKCzeta, Protein, Kinase, 5922, Tocris Bioscience

Citations for CRT 0066854 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for CRT 0066854 hydrochloride. Do you know of a great paper that uses CRT 0066854 hydrochloride from Tocris? Please let us know.

Reviews for CRT 0066854 hydrochloride

There are currently no reviews for this product. Be the first to review CRT 0066854 hydrochloride and earn rewards!

Have you used CRT 0066854 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling