Guanylyl Cyclases

Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. There are two main groups of guanylyl cyclase.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3635 BPIPP
Non-competitive GC inhibitor. Also AC inhibitor
3213 Methylene Blue
Soluble guanylyl cyclase inhibitor
4517 NS 2028
Potent soluble guanylyl cyclase (sGC) inhibitor
0880 ODQ
Selective inhibitor of NO-sensitive guanylyl cyclase
0746 Zinc protoporphyrin IX
Guanylyl cyclase inhibitor. Also inhibits heme oxygenase

Activators

Cat No Product Name / Activity
2753 A 350619 hydrochloride
Soluble guanylyl cyclase (sGC) activator
4430 BAY 41-2272
Soluble guanylyl cyclase (sGC) activator
5708 BAY 41-8543
Guanylyl cyclase (sGC) stimulator
6052 BAY 58-2667 hydrochloride
Potent soluble guanylyl cyclase (sGC) activator
1898 Guanylin (human)
Endogenous activator of intestinal guanylyl cyclase
0756 SIN-1 chloride
Guanylyl cyclase activator
4307 YC 1
Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases.

There are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

External sources of pharmacological information for Guanylyl Cyclases :

    Literature for Guanylyl Cyclases

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    Guanylyl Cyclase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Soluble
    GUCY1α2 Human GUCY1A2 NM_000855 P33402
    Mouse Gucy1a2 NM_001033322 NP_001028494
    Rat Gucy1a2 NM_023956 Q9WVI4
    GUCY1α3 Human GUCY1A3 NM_000856 Q02108
    Mouse Gucy1a3 NM_021896 Q9ERL9
    Rat Gucy1a3 NM_017090 P19686
    GUCY1β2 Human GUCY1B2 NR_003923 O75343
    Mouse Gucy1b2 NM_172810 NP_766398
    Rat Gucy1b2 NM_012770 P22717
    GUCY1β3 Human GUCY1B3 NM_000857 Q02153
    Mouse Gucy1b3 NM_017469 O54865
    Rat Gucy1b3 NM_012769 P20595
    GUCY2G Human GUCY2G XM_497249 -
    Mouse Gucy2g NM_001081076 Q6TL19
    Rat Gucy2g NM_139042 P55205
    Transmembrane
    GUCY2A Human NPR1 NM_000906 P16066
    Mouse Npr1 NM_008727 P18293
    Rat Npr1 NM_012613 P18910
    GUCY2B Human NPR2 NM_003995 P20594
    Mouse Npr2 NM_173788 Q6VVW5
    Rat Npr2 NM_053838 P16067
    GUCY2C Human GUCY2C NM_004963 P25092
    Mouse Gucy2c NM_001127318 Q3UWA6
    Rat Gucy2c NM_013170 P23897
    GUCY2D Human GUCY2D NM_000180 Q02846
    Mouse Gucy2d NM_001130693 NP_001124165
    Rat Gucy2d NM_130737 P51839
    GUCY2E Human GUCY2E XM_001717418 Q3C1W8
    Mouse Gucy2e NM_008192 P52785
    Rat Gucy2e NM_024380 P51840
    GUCY2F Human GUCY2F NM_001522 P51841
    Mouse Gucy2f NM_001007576 Q5SDA5
    Rat Gucy2f NM_053831 P51842