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Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.
(Modifications: Disulfide Bridge between 4 - 12, 7 - 15)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Beltowski (2001) Guanylin and related peptides. J.Physiol.Pharmacol. 52 351 PMID: 11596856
Currie et al (1992) Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc.Natl.Acad.Sci.U.S.A. 89 947 PMID: 1346555
Nokihara et al (1997) Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer. Regul.Pept. 70 111 PMID: 9272623
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Keywords: Guanylin (human), Guanylin (human) supplier, Endogenous, activators, intestinal, guanylyl, cyclase, sGC, Guanylyl, cyclases, Cyclase, 1898, Tocris Bioscience
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