Guanylin (human)

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Cat.No. 1898 - Guanylin (human) | Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (Disulfide bridges: 4 -2*, 7 - 5*) | CAS No. 183200-12-6
Description: Endogenous activator of intestinal guanylyl cyclase
Datasheet
Citations
Reviews
Literature

Biological Activity

Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.

Technical Data

M. Wt 1458.65
Formula C58H87N15O21S4
Sequence PGTCEICAYAACTGC

(Modifications: Cys-15 = C-terminal OH, Disulfide Bridge between 4 - 2, 7 - 5)

Storage Desiccate at -20°C
CAS Number 183200-12-6
PubChem ID 90488722
InChI Key XPNQMTAYRNMRRD-RDJGHUJSSA-N
Smiles [H]N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC1=O)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Beltowski (2001) Guanylin and related peptides. J.Physiol.Pharmacol. 52 351 PMID: 11596856

Currie et al (1992) Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc.Natl.Acad.Sci.U.S.A. 89 947 PMID: 1346555

Nokihara et al (1997) Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer. Regul.Pept. 70 111 PMID: 9272623


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Keywords: Guanylin (human), Guanylin (human) supplier, Endogenous, activators, intestinal, guanylyl, cyclase, sGC, Guanylyl, cyclases, Cyclase, 1898, Tocris Bioscience

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