Guanylin (human)

Pricing Availability Delivery Time Qty
Cat.No. 1898 - Guanylin (human) | Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (Disulfide bridges: 4 -2*, 7 - 5*) | CAS No. 183200-12-6
Description: Endogenous activator of intestinal guanylyl cyclase
Datasheet
Citations
Literature

Biological Activity

Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.

Technical Data

M. Wt 1458.65
Formula C58H87N15O21S4
Sequence PGTCEICAYAACTGC

(Modifications: Cys-15 = C-terminal OH, Disulfide Bridge between 4 - 2, 7 - 5)

Storage Desiccate at -20°C
CAS Number 183200-12-6
PubChem ID 90488722
InChI Key XPNQMTAYRNMRRD-RDJGHUJSSA-N
Smiles [H]N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC1=O)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1458.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.69 mL 3.43 mL 6.86 mL
5 mM 0.14 mL 0.69 mL 1.37 mL
10 mM 0.07 mL 0.34 mL 0.69 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Beltowski (2001) Guanylin and related peptides. J.Physiol.Pharmacol. 52 351 PMID: 11596856

Currie et al (1992) Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc.Natl.Acad.Sci.U.S.A. 89 947 PMID: 1346555

Nokihara et al (1997) Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer. Regul.Pept. 70 111 PMID: 9272623


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Keywords: Endogenous activators intestinal guanylyl cyclase sGC Guanylyl cyclases Guanylyl Cyclase

Citations for Guanylin (human)

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