BAY 58-2667 hydrochloride
Potent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 602.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.66 mL||8.3 mL||16.61 mL|
|5 mM||0.33 mL||1.66 mL||3.32 mL|
|10 mM||0.17 mL||0.83 mL||1.66 mL|
|50 mM||0.03 mL||0.17 mL||0.33 mL|
References are publications that support the biological activity of the product.
Stasch et al (2002) NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br.J.Pharmacol. 136 773 PMID: 12086987
Stasch et al (2006) Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J.Clin.Invest. 116 2552 PMID: 16955146
Roy et al (2008) Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br.J.Pharmacol. 153 1495 PMID: 18204474
If you know of a relevant reference for BAY 58-2667 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: BAY 58-2667 hydrochloride, BAY 58-2667 hydrochloride supplier, BAY58-2667, hydrochloride, potent, soluble, guanylyl, cyclase, activators, activates, antihypertensive, Cinaciguat, Guanylyl, Cyclase, Enzyme, Substrates, /, Activators, 6052, Tocris Bioscience
Citations for BAY 58-2667 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for BAY 58-2667 hydrochloride. Do you know of a great paper that uses BAY 58-2667 hydrochloride from Tocris? Please let us know.
Reviews for BAY 58-2667 hydrochloride
There are currently no reviews for this product. Be the first to review BAY 58-2667 hydrochloride and earn rewards!
Have you used BAY 58-2667 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.