BAY 58-2667 hydrochloride

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Description: Potent soluble guanylyl cyclase (sGC) activator
Alternative Names: Cinaciguat hydrochloride
Chemical Name: 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for BAY 58-2667 hydrochloride

BAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.

Technical Data for BAY 58-2667 hydrochloride

M. Wt 602.16
Formula C36H39NO5.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 646995-35-9
PubChem ID 10031513

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 58-2667 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 60.22 100

Preparing Stock Solutions for BAY 58-2667 hydrochloride

The following data is based on the product molecular weight 602.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.66 mL 8.3 mL 16.61 mL
5 mM 0.33 mL 1.66 mL 3.32 mL
10 mM 0.17 mL 0.83 mL 1.66 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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Product Datasheets for BAY 58-2667 hydrochloride

Certificate of Analysis / Product Datasheet
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References for BAY 58-2667 hydrochloride

References are publications that support the biological activity of the product.

Stasch et al (2002) NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br.J.Pharmacol. 136 773 PMID: 12086987

Stasch et al (2006) Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J.Clin.Invest. 116 2552 PMID: 16955146

Roy et al (2008) Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br.J.Pharmacol. 153 1495 PMID: 18204474

If you know of a relevant reference for BAY 58-2667 hydrochloride, please let us know.

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2 Citations for BAY 58-2667 hydrochloride

Citations are publications that use Tocris products. Selected citations for BAY 58-2667 hydrochloride include:

Cheng et al (2019) Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol ATVBAHA119312725 PMID: 31043077

John et al (2022) Modulation of soluble guanylate cyclase ameliorates pulmonary hypertension in a rat model of chronic thromboembolic pulmonary hypertension by stimulating angiogenesis. Physiol Rep 10 e15156 PMID: 35001565

Do you know of a great paper that uses BAY 58-2667 hydrochloride from Tocris? Please let us know.

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