BAY 58-2667 hydrochloride

Pricing Availability   Qty
Description: Potent soluble guanylyl cyclase (sGC) activator
Alternative Names: Cinaciguat hydrochloride
Chemical Name: 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for BAY 58-2667 hydrochloride

BAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.

Technical Data for BAY 58-2667 hydrochloride

M. Wt 602.16
Formula C36H39NO5.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 646995-35-9
PubChem ID 10031513

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 58-2667 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 60.22 100

Preparing Stock Solutions for BAY 58-2667 hydrochloride

The following data is based on the product molecular weight 602.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.66 mL 8.3 mL 16.61 mL
5 mM 0.33 mL 1.66 mL 3.32 mL
10 mM 0.17 mL 0.83 mL 1.66 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for BAY 58-2667 hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for BAY 58-2667 hydrochloride

References are publications that support the biological activity of the product.

Stasch et al (2002) NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br.J.Pharmacol. 136 773 PMID: 12086987

Stasch et al (2006) Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J.Clin.Invest. 116 2552 PMID: 16955146

Roy et al (2008) Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br.J.Pharmacol. 153 1495 PMID: 18204474

If you know of a relevant reference for BAY 58-2667 hydrochloride, please let us know.

View Related Products by Product Action

View all Guanylyl Cyclase Activators

Keywords: BAY 58-2667 hydrochloride, BAY 58-2667 hydrochloride supplier, BAY58-2667, hydrochloride, potent, soluble, guanylyl, cyclase, activators, activates, antihypertensive, Cinaciguat, Guanylyl, Cyclase, Enzyme, Substrates, /, Activators, 6052, Tocris Bioscience

1 Citation for BAY 58-2667 hydrochloride

Citations are publications that use Tocris products. Selected citations for BAY 58-2667 hydrochloride include:

Cheng et al (2019) Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol ATVBAHA119312725 PMID: 31043077

Do you know of a great paper that uses BAY 58-2667 hydrochloride from Tocris? Please let us know.

Reviews for BAY 58-2667 hydrochloride

There are currently no reviews for this product. Be the first to review BAY 58-2667 hydrochloride and earn rewards!

Have you used BAY 58-2667 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling