SIN-1 chloride

Pricing Availability   Qty
Description: Water-soluble NO donor
Alternative Names: 3-Morpholinylsydnoneimine chloride
Chemical Name: Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)

Biological Activity for SIN-1 chloride

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Technical Data for SIN-1 chloride

M. Wt 206.63
Formula C6H11ClN4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 16142-27-1
PubChem ID 197942
Smiles NC1=C[N+](N2CCOCC2)=NO1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SIN-1 chloride

Solvent Max Conc. mg/mL Max Conc. mM
water 20.66 100
DMSO 20.66 100

Preparing Stock Solutions for SIN-1 chloride

The following data is based on the product molecular weight 206.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.84 mL 24.2 mL 48.4 mL
5 mM 0.97 mL 4.84 mL 9.68 mL
10 mM 0.48 mL 2.42 mL 4.84 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for SIN-1 chloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for SIN-1 chloride

References are publications that support the biological activity of the product.

Maurice and Heslam (1990) Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 37 671 PMID: 2160060

Nishikawa et al (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 220 183 PMID: 6118429

Siegfried et al (1992) Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 260 668 PMID: 1738117

Tanayama et al (1974) Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica 4 175

If you know of a relevant reference for SIN-1 chloride, please let us know.

Keywords: SIN-1 chloride, SIN-1 chloride supplier, Water-soluble, NO, donor, Guanylyl, cyclases, activators, ROS, Donors, sGC, Precursors, Nitric, Oxide, Signaling, Signalling, vasodilator, 3-Morpholinylsydnoneimine, chloride, /, Cyclase, 0756, Tocris Bioscience

1 Citation for SIN-1 chloride

Citations are publications that use Tocris products. Selected citations for SIN-1 chloride include:

Mistry and Garland (1998) Nitric oxide (NO)-induced activation of large conductance Ca2+-dependent K+ channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery. Br J Pharmacol 124 1131 PMID: 9720783

Do you know of a great paper that uses SIN-1 chloride from Tocris? Please let us know.

Reviews for SIN-1 chloride

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used SIN-1 chloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

SIN-1 inhibits the chlorinating activity of MPO.
By Christopher Trummer on 10/15/2018
Assay Type: In Vitro
Species: Other

Effects of SIN-1 (20 μM in pH 7.4, kept at 37 °C for 2 h) on the MPO (10 nM)-H2O2 (25 μM)-chloride system were analyzed by APF fluorescence measurements. Fluorescence intensities were measured every 30 s (up to 30 min) at 488/522 nm (excitation/emission wavelength) at 37 °C. SIN-1 inhibits the chlorinating capacity of MPO.

review image