SIN-1 chloride

Pricing Availability Delivery Time Qty
Cat.No. 0756 - SIN-1 chloride | C6H11ClN4O2 | CAS No. 16142-27-1
Description: Water-soluble NO donor
Alternative Names: 3-Morpholinylsydnoneimine chloride
Chemical Name: Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Technical Data

M. Wt 206.63
Formula C6H11ClN4O2
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 16142-27-1
PubChem ID 197942
InChI Key ZRFWHHCXSSACAW-UHFFFAOYSA-M
Smiles NC1=C[N+](N2CCOCC2)=NO1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.66 100
water 20.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 206.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.84 mL 24.2 mL 48.4 mL
5 mM 0.97 mL 4.84 mL 9.68 mL
10 mM 0.48 mL 2.42 mL 4.84 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Maurice and Heslam (1990) Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 37 671 PMID: 2160060

Nishikawa et al (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 220 183 PMID: 6118429

Siegfried et al (1992) Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 260 668 PMID: 1738117

Tanayama et al (1974) Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica 4 175 PMID:


If you know of a relevant reference for SIN-1 chloride, please let us know.

Keywords: SIN-1 chloride, supplier, Water-soluble, NO, donor, Guanylyl, cyclases, activators, ROS, Donors, sGC, Precursors, Nitric, Oxide, Signaling, Signalling, vasodilator, 3-Morpholinylsydnoneimine, chloride, NO, Donors, /, Precursors, Tocris Bioscience

Citations for SIN-1 chloride

Citations are publications that use Tocris products.

Currently there are no citations for SIN-1 chloride. Do you know of a great paper that uses SIN-1 chloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for SIN-1 chloride

Protocols

TODO: Add Protocols