SIN-1 chloride

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Cat.No. 0756 - SIN-1 chloride | C6H11ClN4O2 | CAS No. 16142-27-1
Description: Water-soluble NO donor
Alternative Names: 3-Morpholinylsydnoneimine chloride
Chemical Name: Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Purity: ≥98% (HPLC)

Biological Activity

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Technical Data

M. Wt 206.63
Formula C6H11ClN4O2
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 16142-27-1
PubChem ID 197942
Smiles NC1=C[N+](N2CCOCC2)=NO1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.66 100
water 20.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 206.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.84 mL 24.2 mL 48.4 mL
5 mM 0.97 mL 4.84 mL 9.68 mL
10 mM 0.48 mL 2.42 mL 4.84 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Maurice and Heslam (1990) Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 37 671 PMID: 2160060

Nishikawa et al (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 220 183 PMID: 6118429

Siegfried et al (1992) Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 260 668 PMID: 1738117

Tanayama et al (1974) Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica 4 175 PMID:

If you know of a relevant reference for SIN-1 chloride, please let us know.

Keywords: SIN-1 chloride, supplier, Water-soluble, NO, donor, Guanylyl, cyclases, activators, ROS, Donors, sGC, Precursors, Nitric, Oxide, Signaling, Signalling, vasodilator, 3-Morpholinylsydnoneimine, chloride, NO, Donors, /, Precursors, Guanylyl, Cyclase, ROS, Donors, NO, Donors, /, Precursors, Tocris Bioscience

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