BAY 41-2272

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Cat.No. 4430 - BAY 41-2272 | C20H17FN6 | CAS No. 256376-24-6
Description: Soluble guanylyl cyclase (sGC) activator
Chemical Name: 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

Compound Libraries

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Technical Data

M. Wt 360.39
Formula C20H17FN6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 256376-24-6
PubChem ID 9798973
InChI Key ATOAHNRJAXSBOR-UHFFFAOYSA-N
Smiles FC(C=CC=C3)=C3CN2N=C(C4=NC=C(C5CC5)C(N)=N4)C1=CC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 360.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Stasch et al (2010) NO-independent regulatory site on soluble guanylate cyclase. Nature 410 212 PMID: 11242081

Joshi et al (2011) The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. J.Pharmacol.Exp.Ther. 339 394 PMID: 21825001

Mittendorf et al (2009) Discovery of Riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. ChemMedChem 4 853 PMID: 19263460


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Keywords: activators soluble guanylyl guanylate cyclases sGC BAY41-2272 Guanylyl Cyclase

Citations for BAY 41-2272

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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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Pathways for BAY 41-2272

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