Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.77 mL||13.87 mL||27.75 mL|
|5 mM||0.55 mL||2.77 mL||5.55 mL|
|10 mM||0.28 mL||1.39 mL||2.77 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
References are publications that support the biological activity of the product.
Stasch et al (2010) NO-independent regulatory site on soluble guanylate cyclase. Nature 410 212 PMID: 11242081
Joshi et al (2011) The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. J.Pharmacol.Exp.Ther. 339 394 PMID: 21825001
Mittendorf et al (2009) Discovery of Riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. ChemMedChem 4 853 PMID: 19263460
If you know of a relevant reference for BAY 41-2272, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BAY 41-2272, BAY 41-2272 supplier, activators, soluble, guanylyl, guanylate, cyclases, sGC, BAY41-2272, Guanylyl, Cyclase, Other, Nitric, Oxide, Enzyme, Substrates, /, Activators, 4430, Tocris Bioscience
Citations for BAY 41-2272
Citations are publications that use Tocris products.
Currently there are no citations for BAY 41-2272. Do you know of a great paper that uses BAY 41-2272 from Tocris? Please let us know.
Reviews for BAY 41-2272
There are currently no reviews for this product. Be the first to review BAY 41-2272 and earn rewards!
Have you used BAY 41-2272?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.