Guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.2||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 420.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||23.78 mL||118.92 mL||237.85 mL|
|0.5 mM||4.76 mL||23.78 mL||47.57 mL|
|1 mM||2.38 mL||11.89 mL||23.78 mL|
|5 mM||0.48 mL||2.38 mL||4.76 mL|
References are publications that support the biological activity of the product.
Stasch et al (2002) Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. Br.J.Pharmacol. 135 333 PMID: 11815368
Hoffmann et al (2015) Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat.Commun. 6 7235 PMID: 26011238
If you know of a relevant reference for BAY 41-8543, please let us know.
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