BAY 41-8543

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Cat.No. 5708 - BAY 41-8543 | C21H21FN8O | CAS No. 256498-66-5
Description: Guanylyl cyclase (sGC) stimulator
Chemical Name: 2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine
Purity: ≥98% (HPLC)

Biological Activity

Guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.

Technical Data

M. Wt 420.44
Formula C21H21FN8O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 256498-66-5
PubChem ID 9953906
Smiles FC1=CC=CC=C1CN2N=C(C3=NC(N)=C(N4CCOCC4)C(N)=N3)C5=CC=CN=C52

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.2 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 420.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Stasch et al (2002) Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. Br.J.Pharmacol. 135 333 PMID: 11815368

Hoffmann et al (2015) Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat.Commun. 6 7235 PMID: 26011238

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Keywords: BAY41-8543 guanylyl cyclase activators activates antihypertensive sGC antiobesity vasorelaxant stimulators stimulate Guanylyl Cyclase

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