BAY 41-8543

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Description: Guanylyl cyclase (sGC) stimulator
Chemical Name: 2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine
Purity: ≥98% (HPLC)

Biological Activity for BAY 41-8543

BAY 41-8543 is a guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.

Technical Data for BAY 41-8543

M. Wt 420.44
Formula C21H21FN8O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 256498-66-5
PubChem ID 9953906
Smiles FC1=CC=CC=C1CN2N=C(C3=NC(N)=C(N4CCOCC4)C(N)=N3)C5=CC=CN=C52

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 41-8543

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.2 10 with gentle warming

Preparing Stock Solutions for BAY 41-8543

The following data is based on the product molecular weight 420.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.78 mL 118.92 mL 237.85 mL
0.5 mM 4.76 mL 23.78 mL 47.57 mL
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL

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References for BAY 41-8543

References are publications that support the biological activity of the product.

Stasch et al (2002) Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. Br.J.Pharmacol. 135 333 PMID: 11815368

Hoffmann et al (2015) Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat.Commun. 6 7235 PMID: 26011238

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Citations for BAY 41-8543

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