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Biological Activity for NS 2028
NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).
Compound Libraries for NS 2028
Technical Data for NS 2028
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NS 2028
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NS 2028
The following data is based on the product molecular weight 269.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.72 mL||18.58 mL||37.17 mL|
|5 mM||0.74 mL||3.72 mL||7.43 mL|
|10 mM||0.37 mL||1.86 mL||3.72 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References for NS 2028
References are publications that support the biological activity of the product.
von Wantoch Rekowski et al (2010) Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase. Bioorg.Med.Chem. 18 1288 PMID: 20036129
Morbidelli et al (2010) The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R824 PMID: 20032260
Olesen et al (1998) Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br.J.Pharmacol. 123 299 PMID: 9489619
If you know of a relevant reference for NS 2028, please let us know.
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1 Citation for NS 2028
Citations are publications that use Tocris products. Selected citations for NS 2028 include:
Ping et al (2019) 17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase. J Biol Chem 294 15577-15592 PMID: 31439665
Do you know of a great paper that uses NS 2028 from Tocris? Please let us know.
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