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ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase.
ODQ is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||3.74||20 with gentle warming|
The following data is based on the product molecular weight 187.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.34 mL||26.72 mL||53.43 mL|
|5 mM||1.07 mL||5.34 mL||10.69 mL|
|10 mM||0.53 mL||2.67 mL||5.34 mL|
|50 mM||0.11 mL||0.53 mL||1.07 mL|
References are publications that support the biological activity of the product.
Boulton et al (1995) Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase. Neuroscience 69 699 PMID: 8596640
Fedele et al (1996) In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br.J.Pharmacol. 119 590 PMID: 8894183
Garthwaite et al (1995) Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol.Pharmacol. 48 184 PMID: 7544433
Hwang et al (1998) Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br.J.Pharmacol. 125 1158 PMID: 9863642
If you know of a relevant reference for ODQ, please let us know.
Keywords: ODQ, ODQ supplier, Selective, inhibitors, inhibits, NO-sensitive, guanylyl, cyclases, sGC, Nitric, Oxide, Signaling, Signalling, Other, Guanylyl, Cyclase, 0880, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for ODQ include:
Bice et al (2014) NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size. Cardiovasc Res 101 220 PMID: 24259501
Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37 PMID: 25900831
Tseng et al (2011) Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism. PLoS One 6 e27187 PMID: 22073284
Yang (2007) Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol 97 3386 PMID: 17376843
Ågren et al (2007) Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors. Am J Physiol Regul Integr Comp Physiol 292 R485 PMID: 16917023
Makara et al (2007) Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors. J Neurosci 27 10211 PMID: 17881527
Fakira et al (2012) Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice. Glia 51 22 PMID: 22789621
Chester et al (2011) Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension. J Neurosci 301 L755 PMID: 21856817
Harnek et al (2011) Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway. Exp Mol Med 11 30 PMID: 21663688
Anselm et al (2007) Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS. Cardiovasc Res 73 404 PMID: 16962569
Newman et al (2007) Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. Eur J Neurosci 25 1619 PMID: 17408433
Dalsgaard et al (2007) Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities. Am J Physiol Heart Circ Physiol 292 H3072 PMID: 17307993
Cameron (2017) Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu. Sci Rep 7 10578 PMID: 28874749
Yoo et al (2010) Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide. J Korean Med Sci 25 1411 PMID: 20890419
McNeish et al (2006) Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery. BMC Cardiovasc Disord 37 1277 PMID: 16556879
Manchope et al (2016) Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO-cGMP-PKG-KATP Channel Signaling Pathway. PLoS One 11 e0153015 PMID: 27045367
Suri et al (2010) Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. Br J Pharmacol 159 566 PMID: 20050852
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830
Cauwels et al (2006) Anaphylactic shock depends on PI3K and eNOS-derived NO. J Clin Invest 116 2244 PMID: 16886062
Padovan-Neto et al (2015) Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways. Mol Cell Neurosci 35 5781 PMID: 25855188
Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. Braz J Med Biol Res 63 383 PMID: 25327839
Galdino et al (2015) Central release of nitric oxide mediates antinociception induced by aerobic exercise. Proc Natl Acad Sci U S A 48 790 PMID: 25517916
Wallace et al (2015) Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine. Proc Natl Acad Sci U S A 3 PMID: 26359240
Namkoong et al (2005) Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells. J Pharmacol Exp Ther 37 588 PMID: 16391520
Sachs et al (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A 101 3680 PMID: 14990791
Tsang et al (2003) Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery. Br J Pharmacol 138 453 PMID: 12569070
Cirino et al (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Am J Physiol Lung Cell Mol Physiol 100 5531 PMID: 12707413
Bellamy and Garthwaite (2002) Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells. Br J Pharmacol 136 95 PMID: 11976273
Villamor et al (2002) Vascular reactivity in intrapulmonary arteries of chicken embryos during transition to ex ovo life. Am J Physiol Regul Integr Comp Physiol 282 R917 PMID: 11832415
Stanford et al (2001) Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. Br J Pharmacol 133 825 PMID: 11454655
Hedlund et al (2000) Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Physiol Rep 97 2349 PMID: 10688876
Casado et al (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Stroke 97 11593 PMID: 11016958
Dick et al (2000) Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus. Br J Pharmacol 129 751 PMID: 10683200
Mundey et al (2000) Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter. Br J Pharmacol 130 489 PMID: 10821775
Haynes (2000) A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle. Br J Pharmacol 130 685 PMID: 10821799
Rach et al (1999) Deficiency in myocardial NO biosignalling after cardiop. arrest: mechanisms and contribution to post-storage mechanical dysfunction. Br J Pharmacol 128 891 PMID: 10556923
Pérez-Vizcaíno et al (1999) Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta. Br J Pharmacol 128 1419 PMID: 10602320
Cogolludo et al (1999) Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta. Br J Pharmacol 126 1025 PMID: 10193784
Aszódi et al (1999) The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J 18 37 PMID: 9878048
Villarroya et al (1999) PF9404C, a new slow NO donor with beta receptor blocking properties. Br J Pharmacol 128 1713 PMID: 10588927
Ho et al (2013) Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats. Cardiovasc Diabetol 12 99 PMID: 23829275
Moonen and Villamor (2011) Developmental changes in mesenteric artery reactivity in embryonic and newly hatched chicks. J Comp Physiol B 181 1063 PMID: 21626136
Chester et al (2009) Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 297 L318 PMID: 19465519
Hoffmann et al (2009) Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation. Br J Pharmacol 157 781 PMID: 19466990
Prieto et al (1998) Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries. Br J Pharmacol 123 1609 PMID: 9605568
Ruiz and Tejerina (1998) Relaxant effects of L-citrulline in rabbit vascular smooth muscle. Br J Pharmacol 125 186 PMID: 9776359
Fonseca et al (1998) No evidence for a significant non-nitrergic, hyperpolarising factor contribution to field stimulation-induced relaxation of the mouse anococcygeus. Br J Pharmacol 124 524 PMID: 9647477
Fedele et al (1996) In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br J Pharmacol 119 590 PMID: 8894183
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