YC 1

Pricing Availability Delivery Time Qty
Cat.No. 4307 - YC 1 | C19H16N2O2 | CAS No. 170632-47-0
Description: Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest
Chemical Name: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole
Purity: ≥99% (HPLC)

Biological Activity

Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

Compound Libraries

YC 1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 304.34
Formula C19H16N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 170632-47-0
PubChem ID 5712
Smiles OCC4=CC=C(O4)C2=NN(CC3=CC=CC=C3)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.43 100
ethanol 15.22 50

Preparing Stock Solutions

The following data is based on the product molecular weight 304.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.43 mL 32.86 mL
5 mM 0.66 mL 3.29 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Ko et al (1994) YC-1, a novel activator of platelet guanylate cyclase. Blood. 84 4226 PMID: 7527671

Martin et al (2001) YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components. Proc.Natl.Sci.U.S.A. 98 12938 PMID: 11687640

Wang et al (2005) YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. J.Pharmacol.Exp.Ther. 312 917 PMID: 15525795

Teixeira et al (2006) Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4 J.Pharmacol.Exp.Ther. 317 258 PMID: 16352702

If you know of a relevant reference for YC 1, please let us know.

View Related Products by Product Action

View all Guanylyl Cyclase Activators

Keywords: YC 1, supplier, YC1, soluble, guanylyl, cyclase, sGC, activators, platelet, aggregation, cGMP, antiproliferatives, G1, cell, cycle, arrest, inducers, p21, CDK2, Guanylyl, Cyclase, Cell, Cycle, Inhibitors, Enzyme, Substrates, /, Activators, Guanylyl, Cyclase, Tocris Bioscience

Citations for YC 1

Citations are publications that use Tocris products.

Currently there are no citations for YC 1. Do you know of a great paper that uses YC 1 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Pathways for YC 1


TODO: Add Protocols