Protein Kinase G

Protein Kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2 and, due to alternative exon splicing, two isoforms of PKG1 - PKG1α and PKG1β.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3028 Rp-8-Br-PET-cGMPS
Protein kinase G inhibitor
1883 cGMP Dependent Kinase Inhibitor Peptide
Inhibitor of protein kinases G and A
1289 KT 5823
Selective protein kinase G inhibitor
5524 Rp-8-pCPT-cGMPS sodium
PKG inhibitor

Related Targets

    Protein kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2. Due to alternative exon splicing two isoforms of PKG1, PKG1α and PKG1β, exist.

    PKG1 and PKG2 are expressed in different cell types, with PKG1 at its highest concentrations in smooth muscle cells and platelets, whilst PKG2 is most abundant in the brain, lungs and intestinal mucosa. PKGs exist as antiparallel homodimers and have roles in smooth muscle relaxation (via phosphorylation of myosin light chain phosphatase), platelet function, spermatozoa metabolism and hemodynamic homeostasis. In addition, it has been suggested that PKG has anticancer properties due to its role in upregulating expression of the tumor suppressor genes p21, p27 and histidine triad protein 1 (HINT1).

    External sources of pharmacological information for Protein Kinase G :

      Literature for Protein Kinase G

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      Protein Kinase G Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      PKG1 Human PRKG1 NM_006258 Q13976
      Mouse Prkg1 NM_001013833 Q9Z0Z0
      Rat Prkg1 NM_001105731 XP_219805
      PKG2 Human PRKG2 NM_006259 Q13237
      Mouse Prkg2 NM_008926 Q61410
      Rat Prkg2 NM_013012 Q64595