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Protein Kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2 and, due to alternative exon splicing, two isoforms of PKG1 - PKG1α and PKG1β.
|Cat No||Product Name / Activity|
|Protein kinase G inhibitor|
|1883||cGMP Dependent Kinase Inhibitor Peptide|
|Inhibitor of protein kinases G and A|
|Selective protein kinase G inhibitor|
Protein kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2. Due to alternative exon splicing two isoforms of PKG1, PKG1α and PKG1β, exist.
PKG1 and PKG2 are expressed in different cell types, with PKG1 at its highest concentrations in smooth muscle cells and platelets, whilst PKG2 is most abundant in the brain, lungs and intestinal mucosa. PKGs exist as antiparallel homodimers and have roles in smooth muscle relaxation (via phosphorylation of myosin light chain phosphatase), platelet function, spermatozoa metabolism and hemodynamic homeostasis. In addition, it has been suggested that PKG has anticancer properties due to its role in upregulating expression of the tumor suppressor genes p21, p27 and histidine triad protein 1 (HINT1).