Fatty Acid Amide Hydrolase

Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.

Products
Background
Gene Data

Inhibitors

Cat No Product Name / Activity
1462 AACOCF3
FAAH inhibitor
3381 AM 1172
FAAH inhibitor; also anandamide uptake inhibitor and CB receptor partial agonist
2836 Arachidonyl serotonin
Dual FAAH inhibitor/TRPV1 antagonist
4574 ARN 272
FAAH-like anandamide transporter (FLAT) inhibitor
3262 JNJ 1661010
Selective, reversible FAAH inhibitor
4715 JZL 195
Dual FAAH and MAGL inhibitor
2452 LY 2183240
FAAH inhibitor; also inhibits anandamide uptake
1815 Palmitoylisopropylamide
Inhibitor of FAAH
4175 PF 3845
Selective FAAH inhibitor
3307 PF 750
Selective FAAH inhibitor
4785 SA 47
Selective FAAH inhibitor
4752 SA 57
Potent FAAH inhibitor
5209 TAK 21d
Potent FAAH inhibitor
4355 TC-F 2
Potent, reversible and selective FAAH inhibitor
4612 URB 597
Potent and selective FAAH inhibitor

Substrates

Cat No Product Name / Activity
0879 Palmitoylethanolamide
FAAH and PAA substrate. Selective GPR55 agonist

Activators

Cat No Product Name / Activity
5210 PDP-EA
FAAH activator

Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine.

FAAH distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.

Fatty Acid Amide Hydrolase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
FAAH1 Human FAAH NM_001441 O00519
Mouse Faah NM_010173 O08914
Rat Faah NM_024132 P97612
FAAH2 Human FAAH2 NM_174912 Q6GMR7