TAK 21d

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Cat.No. 5209 - TAK 21d | C19H17F2N7O | CAS No. 1143578-94-2
Description: Potent FAAH inhibitor
Chemical Name: 4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent FAAH inhibitor; (IC50 values are 0.28 and 0.72 nM, at rat and human FAAH respectively). Displays analgesic effects in vivo models of neuropathic and inflammatory pain. Brain penetrant.

Technical Data

M. Wt 397.38
Formula C19H17F2N7O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1143578-94-2
PubChem ID 57749996
InChI Key JCWVFSJNIBAGQN-UHFFFAOYSA-N
Smiles FC1=CC(C2=NC(N3CCN(C(NC4=CC=CN=N4)=O)CC3)=NC=C2)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 7.95 20
DMSO 3.97 10

Preparing Stock Solutions

The following data is based on the product molecular weight 397.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kono et al (2014) Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. Bioorg.Med.Chem. 22 1468 PMID: 24440478


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Literature in this Area

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