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Biological Activity for TAK 21d
TAK 21d is a potent FAAH inhibitor; (IC50 values are 0.28 and 0.72 nM, at rat and human FAAH respectively). Displays analgesic effects in vivo models of neuropathic and inflammatory pain. Brain penetrant.
Technical Data for TAK 21d
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TAK 21d
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TAK 21d
The following data is based on the product molecular weight 397.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.58 mL||62.91 mL||125.82 mL|
|1 mM||2.52 mL||12.58 mL||25.16 mL|
|2 mM||1.26 mL||6.29 mL||12.58 mL|
|10 mM||0.25 mL||1.26 mL||2.52 mL|
References for TAK 21d
References are publications that support the biological activity of the product.
Kono et al (2014) Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. Bioorg.Med.Chem. 22 1468 PMID: 24440478
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Citations for TAK 21d
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.