PF 3845

Pricing Availability Delivery Time Qty
Cat.No. 4175 - PF 3845 | C24H23F3N4O2 | CAS No. 1196109-52-0
Description: Selective FAAH inhibitor
Chemical Name: N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations

Biological Activity

Selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

PF 3845 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 456.46
Formula C24H23F3N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1196109-52-0
PubChem ID 25154867
InChI Key NBOJHRYUGLRASX-UHFFFAOYSA-N
Smiles O=C(NC2=CN=CC=C2)N1CCC(CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.65 100
ethanol 22.82 50

Preparing Stock Solutions

The following data is based on the product molecular weight 456.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.95 mL 21.91 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.1 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ahn et al (2009) Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem.Biol. 16 411 PMID: 19389627

Ahn et al (2009) Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opin.Drug Discov. 4 763 PMID: 20544003


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Keywords: pfizer cannabinoid receptors fatty acid amide hydrolase FAAH inhibitors inhibits PF3845 Fatty Acid Amide Hydrolase (FAAH)

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