JZL 195

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Description: Dual FAAH and MAGL inhibitor
Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for JZL 195

JZL 195 is a dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown to impair short-term memory in mice.

Compound Libraries for JZL 195

JZL 195 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JZL 195

M. Wt 433.46
Formula C24H23N3O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1210004-12-8
PubChem ID 46232606
Smiles O=C(OC4=CC=C([N+]([O-])=O)C=C4)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JZL 195

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.67 50

Preparing Stock Solutions for JZL 195

The following data is based on the product molecular weight 433.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.61 mL 23.07 mL 46.14 mL
2.5 mM 0.92 mL 4.61 mL 9.23 mL
5 mM 0.46 mL 2.31 mL 4.61 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets for JZL 195

Certificate of Analysis / Product Datasheet
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References for JZL 195

References are publications that support the biological activity of the product.

Wise et al (2012) Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS Chem.Neurosci. 3 369 PMID: 22860205

Long et al (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc.Natl.Acad.Sci.USA 106 20270 PMID: 19918051

Wiskerke et al (2012) Characterization of the effects of reuptake and hydrolysis inhibiton on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem.Neurosci. 3 407 PMID: 22860210

If you know of a relevant reference for JZL 195, please let us know.

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Citations for JZL 195

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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