JZL 195

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Cat.No. 4715 - JZL 195 | CAS No. 1210004-12-8
Description: Dual FAAH and MAGL inhibitor
Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown to impair short-term memory in mice.

Compound Libraries

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Technical Data

M. Wt 433.46
Formula C24H23N3O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1210004-12-8
PubChem ID 46232606
InChI Key QNYRAEKLMNDRFY-UHFFFAOYSA-N
Smiles O=C(OC4=CC=C([N+]([O-])=O)C=C4)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.67 50

Preparing Stock Solutions

The following data is based on the product molecular weight 433.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.54 mL 23.07 mL
5 mM 0.46 mL 2.31 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wise et al (2012) Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS Chem.Neurosci. 3 369 PMID: 22860205

Long et al (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc.Natl.Acad.Sci.USA 106 20270 PMID: 19918051

Wiskerke et al (2012) Characterization of the effects of reuptake and hydrolysis inhibiton on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem.Neurosci. 3 407 PMID: 22860210


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Keywords: JZL 195, supplier, JZL195, FAAH, fatty, acid, amide, hydrolase, monoacylglycerol, lipase, MAGL, inhibitors, inhibits, dual, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, MAGL, Fatty, Acid, Amide, Hydrolase, (FAAH), Tocris Bioscience

Citations for JZL 195

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